尼可地尔对稳定型微血管病性心绞痛的治疗效果  

THE EFFECT OF NICORANDIL ON STABLE MICROVASCULAR ANGINA

作　　者：高希磊 张荃方[1] 张文辉 吕晓冰[4] 辛辉[1] 

机构地区：[1]青岛大学附属医院心血管内科,山东青岛266003 [2]昌乐县人民医院 [3]青岛市李村街道社区卫生服务中心 [4]青岛大学附属医院动态心电图室

出　　处：《青岛大学医学院学报》2016年第3期322-324,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨尼可地尔对稳定型微血管病性心绞痛治疗效果。方法选取稳定型微血管病性心绞痛病人81例,随机分为对照组40例,尼可地尔组41例,两组均给予常规治疗,在常规治疗的基础上,尼可地尔组加用尼可地尔5mg口服,每天3次,两组均治疗4周。观察两组病人治疗前后心绞痛每周发作的次数及治疗心绞痛的效果,观察两组病人治疗前后十二导联静息心电图的变化,记录静息心电图ST段压低导联总个数的变化、ST段压低电压幅度总和的变化,观察治疗期间的药物不良反应。结果尼可地尔组治疗后心绞痛每周发作次数明显下降,与治疗前比较差异有显著性(t=2.357,P<0.05);与治疗后的对照组比较,差异有显著性(t=3.730,P<0.05);尼可地尔组治疗心绞痛的效果与对照组比较,差异有显著性(U=-3.463,P<0.05)。尼可地尔组治疗后十二导联静息心电图ST段压低导联总个数较治疗前明显下降,差异有显著性(t=2.874,P<0.05);与治疗后的对照组比较差异有显著性(t=2.997,P<0.05)。尼可地尔组治疗后ST段压低电压幅度的总和下降,与治疗前比较差异有显著性(t=2.626,P<0.05);与治疗后对照组比较,差异有显著性(t=2.985,P<0.05)。两组病人未见明显不良反应。结论在常规用药的基础上,尼可地尔治疗稳定型微血管病性心绞痛效果显著,不良反应少,安全可靠。Objective To study the effect of Nicorandil on stable microvascular angina（SMA）. Methods Eighty-one patients with SMA were enrolled and randomized to control group（n=40）and Nicorandil group（n=41）.A conventional treatment was offered to patients in the two groups,to those in the Nicorandil group,an additional oral Nicorandil 5mg was given,three times a day.The course of treatment was four weeks in both groups.The weekly episodes of angina pectoris,before and after treatment,in patients of the two groups and the efficacy of therapy were observed.Before and after treatment,the changes of 12-lead resting electrocardiogram（ECG）were observed,the changes of the total number of ST segment depression in resting ECG and the changes of ST segment low voltage ampitude were recorded,and the adverse drug reactions were observed as well. Results After treatment,the number of angina attacks per week in patients of Nicorandil group notably decreased,compared with before treatment,the difference was significant（t=2.357,P〈0.05）,and compared with patients in the control group after treatment,the difference was also significant（t=3.730,P〈0.05）.The difference in the efficacy of therapy between the Nicorandil group and the control group was significant（U=-3.463,P〈0.05）.After treatment,the total number of ST segment depression in 12-lead resting ECG markedly decreased compared with before treatment（t=2.874,P〈0.05）,and compared with the control group after treatment,the difference was significant（t=2.997,P〈0.05）.After treatment,the sum of the low voltage amplitude decreased in ST segment in Nicorandil group,compared with before treatment,the difference was significant（t=2.626,P〈0.05）,compared with the control group after treatment,the difference was significant（t=2.985,P〈0.05）.No adverse reactions were noted in both groups. Conclusion On the basis of routine treatment,the effectiveness of Nicorandil in the treatment of stable microvascular angina is remarkable,safe and reliable wi

关 键 词：尼可地尔 微血管性心绞痛 治疗结果 

分 类 号：R541.4[医药卫生—心血管疾病]