微小核苷酸通过调控钠通道在疾病诊疗中的研究现状  

Micro RNAs play roles in diagnosis and treatment by regulating sodium channels

作　　者：张剑春[1] 孙丽华[1] 

机构地区：[1]哈尔滨医科大学药学院药理教研室,哈尔滨150086

出　　处：《中国临床药理学杂志》2016年第13期1244-1247,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金项目(81000499;81371211)

摘　　要：钠通道的主要功能是选择性允许Na+跨膜运输,传递和维持细胞的兴奋性。微小核苷酸(miRNA)是一类内源性的非编码小RNA分子,能调节转录后靶基因的表达。本文围绕miRNA在疾病中控制钠通道表达的研究进展作一综述,并讨论了其在临床诊断与治疗相关疾病的发展前景。The primary function of sodium channels is selective permission of transmembrane transport of Na＋and transmission as well as maintenance of cell excitability. Micro RNAs（ miRNAs） are a sort of endogenous non- coding small RNA molecules,which can regulate the expression of target genes after transcription. The present article aims to review the researches on the role of miRNAs in regulating the expression of sodium channels and to discuss the development prospect of it in the clinical diagnosis and relative disease treatments.

关 键 词：微小核苷酸 电压门控钠离子通道 上皮钠通道 钠钙交换体1 

分 类 号：R97[医药卫生—药品]