MMP-9及HIF-1α在鼻NK/T细胞淋巴瘤表达中的作用研究  

Study on effect of MMP-9 and HIF-1α expression in nasal NK / T cell lymphoma

作　　者：韦花媚 刘坤平[2] 罗春英[1] 卢运龙[1] 黄永秩[1] 苏群英[1] 陆海善[1] 

机构地区：[1]右江民族医学院附属医院病理科,百色533500 [2]暨南大学附属清远人民医院病理科,清远511500

出　　处：《中国免疫学杂志》2016年第6期863-866,共4页Chinese Journal of Immunology

摘　　要：目的：研究鼻NK/T细胞淋巴瘤组织中基质金属蛋白酶-9（MMP-9）、缺氧诱导因子-1ɑ（HIF-1ɑ）的表达情况及其与患者临床病理特征的关系。方法：选取右江民族医学院附属医院经病理检查确诊为鼻NK/T细胞淋巴瘤患者,收集病理组织蜡块标本46例（病例组）、同期内镜检查取鼻甲黏膜组织经病理学证实为黏膜慢性炎症标本20例（对照组）,分别采用HE染色法和免疫组织化学法处理两组标本,观察两组标本的病理形态、MMP-9及HIF-1ɑ的表达差异,并分析其与患者临床病理特征的关系。结果：病例组的HIF-1α表达阳性率67.39%（31/46）、对照组表达阳性率为6.52%（3/20）,病例组的HIF-1ɑ表达显著的高于对照组（P〈0.05）。病例组的MMP-9表达阳性率71.74%（33/46）、对照组表达阳性率为6.52%（3/20）,病例组的MMP-9表达显著的高于对照组（P〈0.05）。HIF-1ɑ、MMP-9在阳性表达在Ann Arbor分期（Ⅲ～Ⅳ期）、发生淋巴结转移、血管浸润鼻NK/T细胞淋巴瘤患者的患者组织中出现高表达（P〈0.05）。结论：鼻NK/T细胞淋巴瘤患者组织中HIF-1α、MMP-9呈现高表达,并且与患者发生Ann Arbor分期（Ⅲ～Ⅳ期）、发生淋巴结转移、血管浸润具有一定的关系。Objective：To study the expression of MMP-9 in nasal NK/T cell lymphoma, HIF-1a and its relationship with the clinical and pathologic characteristics. Methods：46 cases （ case group） of paraffin block specimens from patients with pathologically confirmed nasal NK/T cell lymphoma were collected from the Affiliated Hospital of Youjiang Medical College For Nationalities,the same period endoscopy turbinate mucosa were confirmed by pathology in 20 cases of chronic inflammation of mucosa specimens （ control group） , respectively HE staining and immunohistochemistry handle two specimens, observation of the expression differences of two groups of specimens of pathological morphology, MMP-9 and HIF-1a, and to analyze its relationship with the clinical and pathological features of the patients. Results： Case group HIF-1a expression rate 67. 39% （31/46）, expression was 6. 52% （3/20） in control group. , the HIF-1a case group were significantly higher than control group （P〈0. 05）. Case group MMP-9 expression rate 71. 74%（33/46）, in the control group expression was 6. 52% （3/20）, MMP-9 expression in the case group was significantly higher than control group （P〈0. 05）. HIF-1a and MMP-9 in positive expression in Ann Arbor staging （Ⅲ-Ⅳ）, lymph node metastasis, vascular invasion in patients with nasal NK/T cell lymphoma tissue appeared a high expression （ P〈 0. 05 ） . Conclusion： Nasal NK/T cell lymphoma tissue of patients with HIF-1a, MMP-9 presented high expression, and there was a certain relationship between Arbor Ann stage （Ⅲ-Ⅳ） , lymph node metastasis and vascular invasion.

关 键 词：鼻NK/T细胞淋巴瘤 基质金属蛋白酶-9 缺氧诱导因子-1Α 临床病理特征 

分 类 号：R392[医药卫生—免疫学]