盐酸安非他酮联合心理干预的戒烟效果评价  

Effectiveness of bupropion and counseling for smoking cessation

作　　者：姜斌[1] 何耀[2] 左芳[1] 吴蕾[2] 刘庆辉[3] 张丽[4] 周长喜[3] 郑家强[5] 陈肇始[5] 林大庆[6] 

机构地区：[1]解放军总医院南楼中医针灸科,北京100853 [2]解放军总医院呼吸科,北京100853 [3]解放军总医院康复医学科,北京100853 [4]英国伯明翰大学 [5]香港大学护理学院 [6]香港大学公共卫生学院

出　　处：《中华预防医学杂志》2016年第7期640-644,共5页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金，英国癌症基金会

摘　　要：目的：评价盐酸安非他酮联合心理干预对戒烟门诊患者戒烟的有效性。方法采用干预研究设计，以2008年10月28日至2014年10月31日在北京某医院戒烟门诊就诊的吸烟者287例做为调查对象，其中156例患者首诊时仅接受标准的心理干预，为心理干预组；131例在接受心理干预的同时接受盐酸安非他酮辅助戒烟，定义为盐酸安非他酮组。比较了随访1、6个月时两组的7d时点戒烟率，随访6个月时两组的持续1个月戒烟率，以及随访1、6个月时两组的减烟率，采用意向性分析的统计学方法分析两组的差异。结果随访1、6个月时，盐酸安非他酮组的7d时点戒烟率均高于心理干预组[随访1个月时，两组戒烟率分别为26.0%（34/131）、15.4%（24/156），OR（95%CI）值为1.93（1.07~3.46）；随访6个月时，两组戒烟率分别为27.8%（35/131）、15.4%（24/156），OR（95%CI）值为2.01（1.12~3.59）；随访6个月时，盐酸安非他酮组持续1个月的戒烟率高于心理干预组，分别为26.0%（34/131）、14.7%（23/156），OR（95%CI）值为2.03（1.12~3.66）。随访1个月时，盐酸安非他酮组的减烟率高于心理干预组，分别为55.0%（72/131）、38.5%（60/156），OR（95%CI）值为1.95（1.22~3.13）。结论在戒烟门诊就诊患者中，给予患者盐酸安非他酮辅助戒烟可有效提高戒烟率和减烟率。Objective To evaluate the effectiveness of bupropion for smoking cessation among Chinese smokers at a smoking cessation clinic. Methods A prospective observational study was conducted in a hospital located in Beijing during 2008 and from 28 to 31 October 2014. A total of 287 smokers （265 men and 22 women） were assessed using data from structured questionnaires at baseline and were followed up at 1 and 6 months. Trained physician counselors provided free brief education and individual counseling sessions for all participants at the first visit. A total 131 participants were prescribed bupropion in addition to counseling. The counseling plus bupropion group was compared with the group who underwent counseling without bupropion. Outcomes were self-reported 7-day point prevalence abstinence rates at 1-and 6-month follow-up and continuous abstinence rates at 6-month follow-up. Smoking reduction rates at 1 and 6 months were also measured. Results By intention-to-treat analysis, the 7-day point prevalence abstinence rate of the bupropion group at 1 and 6 months was higher than for the counseling-only group：at 1-month follow-up, 26.0% （34/131） vs. 15.4% （24/156）, with OR （95%CI） 1.93（1.07-3.46）; these rates at 6-month follow-up were 27.8% （35/131） vs. 15.4% （24/156）, with OR （95%CI） 2.01（1.12-3.59）. The 1-month continuous abstinence rate at 6 months was higher in the bupropion group： 26.0% （34/131） vs. 14.7% （23/156）, with OR （95%CI） 2.03（1.12-3.66）. Participants in the bupropion group also had a higher smoking reduction rate at 1 month than those in the counseling-only group：55.0%（72/131） vs. 38.5%（60/156）, with OR （95%CI） 1.95 （1.22-3.13）. Conclusion Prescription of bupropion at this smoking cessation clinic was effective in＆amp;nbsp;doubling the quitting rates and smoking reduction rates among Chinese smokers.

关 键 词：戒烟 安非他酮 心理干预 

分 类 号：R163[医药卫生—公共卫生与预防医学]