TCF7L2基因rs7903146多态性与2型糖尿病关系的Meta分析  

The relationship between polymorphism of rs7903146 in TCF7L2 gene and 2-diabetes mellitus: a Meta-analysis

作　　者：梁伟[1] 朱丽君[1] 段滢[1] 金岳龙[1] 贺连平[1] 常微微[1] 姚应水[1] 

机构地区：[1]皖南医学院公共卫生学院

出　　处：《中国临床药理学与治疗学》2016年第5期526-532,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目(81441127)

摘　　要：目的:系统评价TCF7L2基因rs7903146多态性与2型糖尿病的关系。方法:通过中国知网(CNKI)和万方数据库及Pub Med全面检索公开发表的关于TCF7L2基因rs7903146多态性的研究,采用Stata 11.0软件对纳入的文献进行Meta分析。结果:最终纳入文献25篇,共纳入25 560例研究对象,糖尿病组13 748例,对照组11 812例。(TT+CT)/CC基因型Meta分析异质性为I^2=72.9%,所以采用随机效应模型合并数据,合并效应量(TT+CT)/CC基因型频率OR值为1.52,95%CI:1.34~1.71,(Z=6.75,P=0.000);东南亚、欧洲、美洲差异有统计学意义,西亚人群中差异无统计学意义;敏感性分析稳定,漏斗图提示不存在发表偏移。等位基因T/C Meta分析异质性为I^2=73.5%,采用随机效应模型;合并效应量等位基因T/C的OR值为1.43,95%CI:1.30~1.57(Z=7.39,P=0.000),各亚组之间差异有统计学意义;敏感性分析稳定,漏斗图提示无发表偏倚。结论:TCF7L2基因rs7903146多态性与2型糖尿病的发生有关,TT+CT基因型是T2DM患者发病的危险因素;等位基因T是T2DM患者发病的危险因素。AIM：To systematically review the relationship between polymorphism of rs7903146 inTCF7L2 gene and 2-diabetes mellitus.METHODS：Researches about rs7903146 inTCF7L2 gene were selected from Chinese National Knowledge Infrastructure,Chinese Wanfang Data Knowledge Service Platform,and Pubmed database.Software Stata 11.0 was applied to do Meta-analysis about these researches.RESULTS：Twenty five studies were eligible for inclusion in the Meta-analysis.There was 25 560 cases in this study which included 13 748 patients in group T2DM and 11 812 healthy people in Control group.Meta-analysis results showed that literature of gentype（TT ＋ TC）/CC had higher heterogeneity （I2 =72.9%）.After combining analysis by using random effect model,the OR value of genotype frequency of effectsize （TT ＋ TC）/CC was 1.52,（95% CI：1.34-1.71,P =0.000）.Significant difference was detected among the population of Southeast Asia,Europe and America while was absent in West Asia.The results of Meta-analysis were stable without significant publication bias after sensitivity analysis and funnel plot of the Begg＆#39;s test and Egger’s test.The random effect model was used to analysis allelic gen of T/C for the higher heterogeneity （I2 =73.5%）.The results were stable and pooled OR 1.43,（95%CI：1.30-1.57,P=0.000）.No publication bias was found in this study.CONCLUSION：There is significant correlation between polymorphism of rs7903146 in TCF7L2 gene and 2-diabetes mellitus.The genotype of TT ＋CT is a risk factor of the incidence of T2DM.The allelic gen of T is alsoa risk factor of T2DM.

关 键 词：TCF7L2基因 2型糖尿病 基因多态性 META分析 

分 类 号：R587.1[医药卫生—内分泌]