纳美芬对新生儿窒息后血浆β-内啡肽表达的影响  

Effect of Nalmefene on the expression of β-Endorphin in blood plasma after neonatal asphyxia

作　　者：包长顺[1] 包文朝[1] 

机构地区：[1]内蒙古民族大学附属医院麻醉科

出　　处：《中国临床药理学与治疗学》2016年第5期558-561,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：内蒙古自治区教育厅项目(NJZY12123)

摘　　要：目的:观察纳美芬对新生儿窒息后的血浆β-内啡肽(β-EP)表达的影响。方法:选择40例出生后发生轻重度窒息的足月新生儿,随机分为2组,纳美芬组和对照组(常规治疗组),每组20例。对照组仅给予常规复苏治疗,纳美芬组在常规复苏治疗基础上给予脐静脉注射纳美芬0.02 mg/kg,两组窒息后均经脐静脉采血检测血浆β-EP,于复苏后6、12、24、48 h分别静脉采血检测血浆β-EP及血气分析。结果:两组窒息即刻β-EP及血气分析无统计学意义(P>0.05),纳美芬组6、12、24 h与对照组及组内比较β-EP显著性降低(P<0.01),对照组6 h后组内比较β-EP较窒息后显著增高(P<0.05),48 h后两组组间及组内比较β-EP均下降明显(P<0.05)。结论:用纳美芬治疗新生儿窒息可以显著性降低β-EP,并改善血气从而减轻缺氧后对心脑细胞再灌注损伤。AIM：To observe the effect of nalmefene on the expression of β-endorphin （β-EP）in the plasma after neonatal asphyxia.METHODS：40 cases of full-term infant with slight and severe asphyxia after birth were randomly divided into two groups,the nalmefene group and the control group （conventional treatment）.There were 20 cases in each group.The control group received conventional resuscitation treatment while the observation group was injected with 0.02 mg/kg nalmefene to umbilical vein in addition to receiving conventional resuscitation treatment.β-endorphin in the plasma by umbilical veins blood collection at the time of asphyxia happened immediately and β-endorphin in the plasma by umbilical veins blood collection and the results of blood gas analysis at 6,12,24,48 h after resuscitation were examined.RESULTS：β-endorphin and results of blood gas analysis had no statistical significance at the time of asphyxia happened immediately in both of the groups （P 〉0.05）.β-endorphin was reduced significantly in observation group at the time of 6,12,24 h compared with control group and there were significant differences in the same group （P 〈 0.01）,β-endorphin in the control group after 6 h increased significantly compared with that after asphyxia in the same group （P 〈 0.05）,β-endorphin decreased significantly after 48 h between the two groups and in the same group （P 〈 0.05）.CONCLUSION：Use of nalmefene can reduce β-EP significantly in neonatal asphyxia,improve blood gas outcome and reduce cardio-cerebral cell repetitionus injury after hypoxia.

关 键 词：纳美芬 新生儿窒息 治疗 血浆Β-内啡肽 

分 类 号：R722.12[医药卫生—儿科]