沙门菌鞭毛蛋白作为偶联疫苗载体的应用  

Application of Salmonella flagellin as carrier protein of conjugate vaccine

作　　者：钱锋[1] 徐沪济[1] 

机构地区：[1]第二军医大学附属长征医院风湿免疫科,上海200003

出　　处：《中国生物制品学杂志》2016年第7期765-769,共5页Chinese Journal of Biologicals

摘　　要：鞭毛蛋白是细菌鞭毛的主要成分,通过聚合鞭毛蛋白单体形成鞭毛的丝状体。鞭毛蛋白的N-末端和C-末端区域相互靠拢形成功能区域,该区域处于鞭毛丝状体的内部;中间区域是序列变异区,暴露于鞭毛丝状体表面。沙门菌鞭毛蛋白具有特殊的抗原性,称为H抗原,是沙门菌分型的依据之一。作为Toll样受体5(Toll-like receptors 5,TLR5)等先天性免疫系统受体的配体,沙门菌鞭毛蛋白是一种强效的蛋白型佐剂,已广泛应用于细菌、病毒和寄生虫的疫苗研制。本文就沙门菌鞭毛蛋白作为载体蛋白在偶联疫苗的应用作一综述。Flagellin is a main component of bacterial flagella.By polymerization,flagellin monomers form flagellar filament.The N-and C-terminal regions of flagellin are in close proximity and compose its functional domain which is buried in the center of filament.The central fragment of flagellin is a variable region exposed on the surface of filament.Salmonella flagellin is named as H-antigen because of its antigen specificity,which is employed as a basis for Salmonella serotyping.As a ligand of some innate immune system receptors such as Toll-like receptor 5（TLR5）,Salmonella flagellin is a potent protein-adjuvant and widely used in the preparation of vaccines against bacteria,viruses and parasites.In this article,the application of Salmonella flagellin as a carrier protein of conjugate vaccine is reviewed.

关 键 词：沙门菌 鞭毛蛋白 偶联疫苗 载体蛋白 

分 类 号：R378.22[医药卫生—病原生物学] R392-33[医药卫生—基础医学]