围生期心肌病患者血清甲状腺激素的变化  

Changes of thyroid hormones in patients with peripartum cardiomyopathy

作　　者：何飞[1] 张杰[1] 郭荣[2] 梁莹[1] 

机构地区：[1]郑州大学第一附属医院心内科,450052 [2]郑州大学第一附属医院血液内科,450052

出　　处：《实用医学杂志》2016年第13期2127-2129,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81070445);河南省医学科技攻关计划项目(编号:201403030;201403029);河南省卫生科技创新型人才工程中青年科技创新人才计划项目

摘　　要：目的:探讨围生期心肌病患者血清甲状腺激素的变化。方法:测定72例围生期心肌病患者(观察组)外周血中的游离三碘甲状腺原氨酸(FT3)、甲状腺素(FT4)、促甲状腺素(TSH)、高敏C反应蛋白(hs-CRP)、γ-干扰素(IFN-γ)和白细胞介素-4(IL-4),以同期正常分娩的72例健康女性作为对照组。结果:观察组血清FT3、FT4水平均显著高于对照组(P<0.05),而其血清TSH水平显著低于对照组(P<0.05)。观察组中有24例甲状腺功能亢进症患者,而对照组中无甲状腺功能亢进症患者(P<0.05)。观察组血浆hs-CRP和IFN-γ水平均显著高于对照组(P<0.05),而其血浆IL-4水平显著低于对照组(P<0.05)。结论 :甲状腺激素水平在围生期心肌病患者中升高,其机制可能与异常的免疫反应有关。Objective To investigate the changes of thyroid hormones in patients with peripartum car- diomyopathy. Methods Seventy-two patients with peripartum cardiomyopathy were consecutively enrolled and 72 healthy women who had normal delivery were regarded as control. Among all the subjects, free triiodothyronine （FT3）, free thyroxine （FT4） and thyroid-stimulating hormone （TSH） in the serum and high sensitive C-reactive protein （hs-CRP）, interferon-gamma （IFN-γ） and interleukin-4 （IL-4） in the plasma were measured. Results The levels of serum Fr3 and FT4 in peripartum cardiomyopathy group were significantly higher than those in control group （P 〈 0.05）. And the level of serum TSH in peripartum cardiomyopathy group was significantly low- er than that in control group （P 〈 0.05 ）. There were 24 cases with hyperthyroidism in peripartum cardiomyopa- thy group while no patient in the control group had hyperthyroidism （P 〈 0.05）. The levels of plasma hs-CRP and IFN-γ in peripartum cardiomyopathy group were significantly higher than those in the control group （P 〈 0.05）. And the level of IL-4 in peripartum cardiomyopathy group was significantly lower than that in the control group （P 〈 0.05 ）. Conclusions Serum thyroid hormones elevated in patients with peripartum cardiomyopathy and its mechanism might be related to abnormal immune reaction.

关 键 词：围生期心肌病 甲状腺激素 免疫反应 

分 类 号：R714.7[医药卫生—妇产科学]