复方骆驼蓬子水凝胶贴剂处方工艺研究  

Optimized formulation of the Compound Luotuopengzi Hydrogel Patch

作　　者：李岩[1] 孙婷[1] 赵欣[1] 孟庆勇[1] 李岩[1] 王长虹 

机构地区：[1]新疆医科大学药学院药剂物化教研室,乌鲁木齐830011 [2]上海中医药大学中药研究所中药标准化教育部重点实验室中药新资源与质量标准综合评价国家中医药管理局重点研究室上海市复方中药重点实验室,上海201210

出　　处：《西北药学杂志》2016年第2期176-180,共5页Northwest Pharmaceutical Journal

基　　金：新疆维吾尔自治区科技支撑项目(编号:201433104)

摘　　要：目的筛选复方骆驼蓬子水凝胶贴剂基质材料的种类、用量和最优处方。方法以复合黏度、涂展性及其他重要性能为评价指标,利用单因素和正交设计实验进行筛选。结果筛选出最优处方为:NP700 5g,甘羟铝0.4g,酒石酸0.4g,甘油50g,聚乙烯吡咯烷酮(PVPK-30)2g,水32.2g,氮酮2.5g+丙二醇2.5g,浸膏5g,处方总量100g。结论成型的复方骆驼蓬子水凝胶贴剂处方工艺稳定、合理可行。Objective To screen the matrix material type ,dosage and optimal formulation of the Compound Luotuopengzi Hydrogel Patch .Meth‐ods With the complex viscosity ,spreadability and other key performance as the index ,the preparation was optimized by using the single factor and orthogonal design .Results The optimal formulation was NP700 5 g ,aluminum glycinate 0 .4 g ,tartaric acid 0 .4 g ,glycerin 50 g ,poly‐vinyl network oxazolidinone （PVPK‐30） 2 g ,water 32 .2 g ,azone 2 .5 g＋propanediol 2 .5 g ,extract 5 g ,and the total prescription 100 g . Conclusion The optimized formulation and process for Compound Luotuopengzi Hydrogel Patch were stable ,reasonable and feasible .

关 键 词：复方骆驼蓬子水凝胶贴剂 基质材料 最优处方 

分 类 号：R944[医药卫生—药剂学]