N-羟基-1,6-亚甲基桥[10]轮烯-3,4-酰亚胺/乙酸钴液相催化氧化3-甲基吡啶制备烟酸  

Synthesis of Nicotinic Acid by Liquid-phase Oxidation ofβ-Picoline Catalyzed by N-hydroxyl-1,6-methano[10]annulene-3,4-dicarboximide/Cobalt(Ⅱ) Acetate

作　　者：廖波[1] 刘建军[1] 李保山[1] 左胜利[1] 

机构地区：[1]北京化工大学理学院,北京100029

出　　处：《合成化学》2016年第7期635-638,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以1,6-亚甲基桥[10]轮烯-3,4-二甲酸酐为原料,与羟胺基盐酸盐经酰化和脱水反应制得N-羟基-1,6-亚甲基桥[10]轮烯-3,4-酰亚胺（2）;构建了2/乙酸钴催化体系,以氧分子为氧源,乙腈为溶剂,在1 MPa氧气压力下于120℃反应20 h,氧化3-甲基吡啶制备烟酸,产率70%,其结构经-1H NMR和IR确证。Synthesis of N-hydroxy-1,6-methano [ 10 ] annulene-3,4-dicarboximide （ 2 ） was accom- plished by acylation and dehydration of hydroxylamine hydrochloride using 1,6-methano [ 10 ] annulene- 3,4-dicarboxylic anhydride as starting material. 2/Cobalt（II） acetate catalytic system was built by u- sing oxygen molecule as oxygen source and acetonitrile as solvent. The yield of nicotinic acid was 70% after oxidative reaction of β-picoline at 120 ℃ for 20 h with 1 MPa of oxygen pressure. The structure was confirmed by l H NMR and IR.

关 键 词：N-羟基-1 轮烯-3 4-酰亚胺 3-甲基吡啶 烟酸 催化 制备 

分 类 号：O626[理学—有机化学]