复方苦芩总黄酮对免疫抑制小鼠免疫功能的影响  

Effect of the Total Flavonoids in Kuqin Compound on Immune Function of Immunosuppressed Mice

作　　者：刘付国树 刘俊玮[1] 朱兆荣[1] 罗艺晨[1] 邱洪[1] 赖建彬[1] 刘娟[1] 

机构地区：[1]西南大学(荣昌校区)兽医科学研究中心中药创新研究室,重庆荣昌402460

出　　处：《西南大学学报（自然科学版）》2016年第7期25-29,共5页Journal of Southwest University(Natural Science Edition)

基　　金：公益性行业(农业)科研专项(201303040);国家自然科学基金(31172357);科技基础性工作专项(2013FY110600)

摘　　要：为了观察复方苦芩总黄酮对免疫抑制小鼠的免疫增强作用,用环磷酰胺构建小鼠免疫抑制模型,给免疫抑制小鼠灌服复方苦芩总黄酮,检测碳粒廓清指数,脾脏指数,胸腺指数,血清溶血素水平及T,B淋巴细胞转化率.结果显示:复方苦芩总黄酮能够提高免疫抑制小鼠的碳粒廓清指数、脾脏指数、胸腺指数,同时也能够提高小鼠血清溶血素水平和增强T,B淋巴细胞转化率,与模型组比较差异极具有统计学意义(p<0.01),且高剂量和中剂量组效果优于低剂量组,差异具有统计学意义(p<0.05)或者极具有统计学意义(p<0.01).表明复方苦芩总黄酮能增强机体的免疫功能.In order to study the effects of the total flavonoids in Kuqin compound on immunosuppressed mice.The model of immune suppression in mice was induced by cyclophosphamide and the immunosuppressed mice were fed by the total flavonoids in Kuqin compound,then detected the carbon clearance index,the spleen index,the thymus index,the serum hemolysim and the T,B lymphocyte proliferation rate in immunosuppressed mice.The results showed that the total flavonoids in Kuqin compound could increased the carbon clearance index,the immune organ index,the serum hemolysim and enhanced the T,B lymphocyte proliferation rate in immunosuppressed mice.The difference was significant compared with model group（p〈0.01）,and the effect of high-dose group,mid-dose group were better the low-dose group,appeared difference（p〈0.05）or significant difference（p〈0.01）.Therefore the total flavonoids in Kuqin compound could increase the body＇s immune function.

关 键 词：复方苦芩总黄酮 免疫抑制 免疫功能 

分 类 号：S853.75[农业科学—临床兽医学]