纳米金/石墨烯/硫辛酰胺修饰的金电极对儿茶酚的催化氧化  

Catalytic Oxidation of Catechol at Gold Nanoparticles/Graphene/Thioctic Acid Amide-Modified Gold Electrode

作　　者：王娜[1] 李献锐[1] 王贝贝[1] 赵海燕[2] 籍雪平[1] 

机构地区：[1]河北医科大学基础医学院,石家庄050017 [2]北京大学人民医院药剂科,北京100044

出　　处：《西南大学学报（自然科学版）》2016年第7期133-137,共5页Journal of Southwest University(Natural Science Edition)

基　　金：河北省自然科学基金(2016206150)

摘　　要：利用电化学还原的方法将还原氧化石墨烯（ERGO）和纳米金（AuNPs）电沉积到硫辛酰胺（T-NH2）修饰的金电极表面,研究了儿茶酚在该修饰电极上的电化学行为.实验表明,在0.10mol/L磷酸缓冲（pH=7.0）溶液中,该修饰电极对儿茶酚具有良好的电催化作用,儿茶酚氧化峰电位比未修饰的金电极负移了80 mV,氧化还原峰电流增大很多,响应电流与儿茶酚浓度在1.40×10-6~9.42×10-3 mol/L范围内呈良好的线性关系,检测的灵敏度为2 682.8μA·（mmol/L）/cm2,检测下限为7.00×10-7 mol/L.此电极具有较好的重现性和稳定性.对样品进行测定及加标回收实验,回收率在97.3%~103.0%之间.Based on direct electrodeposition of electrochemically reduced graphene oxide（ERGO）-Au nanoparticles（AuNPs）on thioctic acid amide（T-NH2）self-assembled monolayers,a novel electrochemical sensor（SAMs）-modified gold electrode has been developed for the electrochemical response of catechol（CT）.The modified electrode shows an excellent catalysis for catechol oxidation in a 0.10 mol/L phosphate buffer solution（pH 7.0）.The peak potential shifts negatively to 80 mV on the modified gold electrode compared with the unmodified gold electrode,and the anodic and cathodic currents increase obviously.The current value is in a good linear relationship with catechol concentration over the range of 1.40×10-6 mol/L to 9.42×10-3 mol/L.The sensitivity is 2 682.8μA·（mmol/L）/cm2 and the detection limit is7.00×10-7 mol/L.The electrode has a satisfactory reproducibility and stability.This method has been successfully used in the determination of catechol in injection with the recovery between 97.3%-103.0%.

关 键 词：儿茶酚 石墨烯 纳米金 修饰电极 

分 类 号：O657.1[理学—分析化学]