机构地区:[1]广州医科大学研究生学院,广东省广州市510000 [2]海南省第三人民医院心内科,海南省三亚市572000 [3]海南省第三人民医院放射科,海南省三亚市572000 [4]海南省第三人民医院检验科,海南省三亚市572000
出 处:《中国动脉硬化杂志》2016年第7期683-687,共5页Chinese Journal of Arteriosclerosis
基 金:海南省医药卫生科研项目(1421320.24A1005);三亚市医疗卫生科技创新项目(2014YW19)
摘 要:目的研究高胆固醇血症患者跟腱厚度(ATT)的相关影响因素,对高胆固醇血症伴有跟腱增厚的患者进行综合防治。方法收集2014年3月至2015年3月年龄在18~70岁之间的高胆固醇血症患者104例,其中男性50例,女性54例。将患者分为ATT增厚组(ATT≥9 mm)和ATT正常组(ATT〈9 mm),比较两组之间一般临床资料的差异,并采用Logistic回归模型对高胆固血症患者ATT的相关因素进行单因素和多因素分析。结果 ATT增厚组和ATT正常组在体重(63.70±11.16 kg比56.45±9.96 kg)、身高(162.91±6.48 cm比160.08±6.90 cm)、体质指数(24.03±3.30 kg/m2比22.17±2.83 kg/m2)、总胆固醇(8.47±1.39 mmol/L比7.67±1.94 mmol/L)、低密度脂蛋白胆固醇(6.14±0.99 mmol/L比5.12±0.13 mmol/L)、高密度脂蛋白胆固醇(1.17±0.42 mmol/L比1.97±1.31 mmol/L)、载脂蛋白AI(1.18±0.26 mmol/L比1.62±0.21 mmol/L)方面差异具有统计学意义。Logistic单因素回归分析显示,不同身高(OR=1.604,95%CI为1.002~1.129)、体质指数(OR=1.271,95%CI为1.064~1.390)、总胆固醇(OR=1.391,95%CI为1.014~1.715)、高密度脂蛋白胆固醇(OR=0.028,95%CI为0.007~0.115)、低密度脂蛋白胆固醇(OR=2.385,95%CI为1.494~3.807)、载脂蛋白AI(OR=0.006,95%CI为0.001~0.046)的高胆固醇血症患者ATT差异显著。Logistic多因素回归分析显示,在高胆固醇血症患者中,低密度脂蛋白胆固醇(OR=1.871,95%CI为1.067~3.280)是ATT的独立危险因素,高密度脂蛋白胆固醇(OR=0.099,95%CI为0.017~0.573)和载脂蛋白AI(OR=0.035,95%CI为0.003~0.412)为ATT的保护性因素。结论伴有ATT增厚的高胆固醇血症患者具有更高的血清胆固醇水平,低密度脂蛋白胆固醇为独立危险因素,高密度脂蛋白胆固醇和载脂蛋白AI为保护性因素。因此,应该对伴有ATT增厚的高胆固醇血症患者的危险因素进行防治,强化降胆固醇治疗。Aim To analyze the correlation factors of achilles tendon thickness in patients with hypercholesterolemia,and offer comprehensive prevention and treatments for patients with hypercholesterolemia accompanied by achilles tendon thickening. Methods 104 patients( 50 males and 54 females) with hypercholesterolemia,aged between 18 and 70 years old,were enrolled into this study from March 2014 to March 2015. They were divided into achilles tendon thickening group of 41 cases and achilles tendon normal group of 64 cases,comparing the differences of general clinical data between the two groups,and single and multiple regression analysis were made to assess the correlation factors of achilles tendon thickness in hypercholesterolemia patients. Results There existed significant difference in body weight( 63.70±11.16 kg vs. 56.45±9.96 kg),height( 162.91±6.48 cm vs. 160.08±6.90 cm),body mass index( 24.03±3.30 kg / m2 vs.22.17±2. 83 kg / m2),the level of TC( 8.47±1.39 mmol/L vs. 7.67±1.94 mmol/L),the level of LDLC( 6.14± 0.99 mmol / L vs. 5.12±0.13 mmol / L),the level of HDLC( 1.17±0.42 mmol / L vs. 1.97±1.31 mmol / L) and the level of apolipoprotein AI( 1.18±0.26 mmol / L vs. 1.62± 0.21 mmol / L) between the achilles tendon thickening group and the achilles tendon normal group in patients with hypercholesterolemia. Univariate Logistic regression analysis showed that the achilles tendon thickness had significant difference in different height( OR = 1.604,95% CI was 1.002 ~ 1.129),body mass index( OR= 1.271,95%CI was 1.064~1.390),TC( OR= 1.391,95%CI was 1.014~1.715),HDLC( OR= 0.028,95%CI was0.007 ~ 0.115),LDLC( OR = 2.385,95%CI was 1.494 ~ 3.807),Apo AI( OR = 0.006,95%CI was 0.001 ~ 0.046) in hypercholesterolemia patients. Multiple Logistic regression analysis showed that LDLC( OR = 1. 871,95% CI was 1. 067 ~3.280) was risk factor while HDLC( OR = 0.099,95%CI was 0.017 ~ 0.573) and apolipoprotein AI( OR = 0.035,95% CI was 0.003 ~ 0.
关 键 词:高胆固醇血症 跟腱厚度 跟腱黄色瘤 直接数字化X线摄影术
分 类 号:R54[医药卫生—心血管疾病]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...