结核杆菌DNA、ADA、γ-IFN检测对结核性胸腔积液的诊断价值分析  

Analysis on the Diagnostic Value of Mycobacterium Tuberculosis DNA, ADA, γ-IFN Detection for Tuberculous Pleural Effusion

作　　者：黄丽君 林坤培 

机构地区：[1]广东省罗定市人民医院,广东罗定527200

出　　处：《临床医学工程》2016年第7期917-918,共2页Clinical Medicine & Engineering

摘　　要：目的研究结核杆菌DNA、腺苷脱氨酶(ADA)以及γ-干扰素(γ-IFN)检测对结核性胸腔积液患者的临床诊断价值。方法将我院60例结核性胸腔积液患者设为研究组,60例恶性胸腔积液患者设为对照组。分别对两组患者进行结核杆菌DNA、ADA以及γ-IFN检测,并比较两组的检测结果。结果研究组患者ADA、γ-IFN水平明显高于对照组(P<0.05)。研究组ADA检测敏感性、特异性分别为86.67%、92.94%,明显高于对照组的6.67%、12.48%;研究组γ-IFN检测敏感性、特异性分别为95.00%、95.67%,明显高于对照组的3.33%、3.33%(均P<0.05)。研究组结核杆菌DNA检测阳性率为38.33%,明显高于对照组的1.67%(P<0.05)。结论结核杆菌DNA、ADA以及γ-IFN检测对结核性胸腔积液均具有较高的临床诊断价值,其中尤以γ-IFN的诊断效能最高。Objective To study the clinical diagnostic value of mycobacterium tuberculosis DNA, adenosine deaminase（ADA） andγ-IFNdetection in patients with tuberculous pleural effusion（TB PE）. Methods 60 TB PE patients in our hospital were set as study group, 60 MPE patients were set as control group. The mycobacterium tuberculosis DNA, ADA and γ-IFNin two groups were detected and the results were compared. Results The levels of A D A and γ-IFNin study group were significantly higher than those in control group（P〈0.05）. The A D A detection sensitivity and specificity in study group were significantly higher than those in control group（86.67% vs 6.67%, 92.94% vs1 2.48%）; the γ-IFNdetection sensitivity and specificity were significantly higher than those in control group（95.00% vs 3.33%, 95.67% vs3.33%）, both P〈0.05. The D NA detection positive rate of mycobacterium tuberculosis in study group was significantly higher than that in control group（38.33% vs 1.67%, P〈0.05）. Conclusions Mycobacterium tuberculosis DNA, ADA and γ-IFNdetection has higher clinical diagnostic value in tuberculous pleural effusion, especially the γ-IFN.

关 键 词：结核杆菌 胸腔积液 腺苷脱氨酶 Γ-干扰素 检测 诊断 

分 类 号：R446.1[医药卫生—诊断学]