老年冠心病患者外周血内脂素的改变及其临床意义  

The expression of serum Visfatin in elderly patients with coronary heart disease and its clinical value

作　　者：何丽华[1] 罗国宏[1] 王斌[1] 

机构地区：[1]四川省南充市第二人民医院检验科,四川南充637000

出　　处：《临床和实验医学杂志》2016年第11期1057-1059,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的检测老年冠心病患者外周血内脂素的改变,并分析其临床意义。方法回顾性分析2012年1月至2014年1月接受治疗的老年冠心病患者的临床资料,列为观察组81例。另纳入同期接受体检的健康老年人作为对照组70例。检测两组外周血内脂素及相关细胞因子的表达,并分析其意义。结果观察组患者外周血内脂素及同型半胱氨酸（HCY）水平均显著高于对照组,差异均具有统计学意义（P〈0.05）。观察组患者外周血内脂素与HCY呈现显著正相关,差异具有统计学意义（r=0.802,P〈0.05）。ROC曲线分析显示,以2.67μg/L为截点值,内脂素诊断冠心病的敏感性为91.36%,特异性为94.29%,优于HCY。将观察组患者分为内脂素高水平组（〉3.65μg/L,n=40）及低水平组（≤3.65,n=41）,K-M分析显示高水平组患者1年累积急性冠脉综合征发生率显著高于低水平组,差异具有统计学意义（37.50%,15/40 vs.17.07%,7/41;Log-rankχ^2=4.571,P=0.033）。结论老年冠心病患者外周血内脂素水平显著升高,且其水平升高提示预后不良。Objective Our study was aimed to analyze the expression of serum visfatin in elderly patients with coronary heart disease and its clinical value. Methods Clinical data of patients with coronary heart disease received treatment at our hospital from 2012 to 2014. All these patients were considered as Group A. Healthy cases were enrolled as Group B. Results A total of 151 cases were analyzed,Group A 81 cases, Group B 70 cases. Group A patients had higher levels of HCY and visfatin than these of Group B,the difference were statistically significant（ P〈 0. 05）. Correlation analysis showed thatthe levels of HCY had significant positive correlation with visfatin for Group A patients（ r = 0. 802,P〈 0. 05）. ROC analysis showed that the visfatin cut - off point value of 2. 67 μg/ L,which was used for the diagnosis of coronary heart disease, and provided a sensitivity of 91. 36% ,a specificity of 94. 29% ,better than these of HCY. Group A patients with higher levels of visfatin（ 〉 3. 65 μg/ L,n = 40）had higher 1 year accumulating incidence of acute coronary syndrome than that of patients with lower levels of visfatin（≤3. 65, n = 41）,the difference was statistically significant（37. 50% ,15 / 40 vs. 17. 07% ,7 / 41;Log - rank χ^2 = 4. 571,P = 0. 033）. Conclusion The levels of visfatin increased significantly in elderly patients with coronary heart disease,which indicated a bad prognosis.

关 键 词：冠心病 内脂素 细胞因子 预后 老年 

分 类 号：R541.4[医药卫生—心血管疾病]