社区老年健康男性骨质疏松患病率调查及临床危险因素分析  

Survey on the prevence of osteoporosis and osteoporosis- related clinical risk factors among community- dwelling healthy elderly male population

作　　者：李东[1] 张效栋[1] 费琦[1] 李永锦 林吉生[1] 孔令波[2] 马钊[1] 王炳强[1] 杨雍[1] 李健[1] 

机构地区：[1]首都医科大学附属北京友谊医院骨科,北京100050 [2]北京市朝阳区团结湖社区卫生服务中心,北京100026

出　　处：《临床和实验医学杂志》2016年第11期1127-1130,共4页Journal of Clinical and Experimental Medicine

基　　金：2013北京市科学技术委员会“首都市民健康项目培育”(编号:Z131100006813040)

摘　　要：目的调查健康老年男性的骨密度(BMD)变化规律并分析和原发性骨质疏松症(OP)相关的临床危险因素。方法在北京市朝阳区团结湖社区采用广告招募的抽样方法,对50岁以上健康老年男性接受自制《北京市老年男性原发性骨质疏松症高危人群临床危险因素调查问卷》调查的同时进行双能X线骨密度检查,记录腰椎总(L1-4)、左侧股骨颈(femoral neck)和左髋总(total hip)的BMD数值和年龄、体重、既往脆性骨折史、吸烟史、饮酒史等临床危险因素;根据世界卫生组织诊断标准将研究对象分为OP组和非OP组,分析各临床危险因素与OP发生的相关性。结果 518例老年男性总体OP患病率14.3%(74/518),骨量减少者53.7%(278/518),骨量正常者32.0%(166/518)。既往脆性骨折史、体重指数、体重在OP组和非OP间存在显著差异性(P<0.05)。结论社区健康老年男性OP患病情况不容乐观,低体重及低体重指数、既往脆性骨折史可能是OP相关的临床危险因素,有待于进一步深入研究。Objective To survey the prevalence of osteoporosis and osteoporosis - related clinical risk factors in community - dwelling healthy elderly male population. Methods By using sampling method of recruitment advertising,healthy elderly males aged 50 and above in Bei-jing Tuanjiehu community had completed our questionnaire were enrolled in this study and they had been accepted testing of bone mineral density （BMD）by using dual energy X - ray absorptiometry. These inhabitants had been classified as osteoporosis group（OP group）and non - osteoporo-sis group（Non - OP group）according to the WHO criteria. Osteoporosis was arbitrarily defined when any T - scores were - 2. 5 standard devia-tions or less at femoral neck,total hip or lumbar spine（L1 - 4 ）. The clinical risk factors of each person including age,body weight,body mass in-dex（BMI）,previous history of fragile fracture,smoking,alcohol abuse,glucocorticoid therapy and other capable clinical risk factors were collect-ed and compared in OP group and Non - OP group. Results Among 518 persons,14. 3%（74 / 518）of them had osteoporosis,53. 7%（278 /518）had osteopenia and 32. 0%（166 / 518）had normal bone mass. There was significant difference in weight,BMI and previous history of frag-ile fracture between OP group and Non - OP group（ P 〈 0. 05）. Conclusion The prevalence of osteoporosis in healthy elder men should not be ignored. Low BMI,weight and previous history of fragile fracture may be osteoporosis - related clinical risk factors in this population.

关 键 词：骨质疏松症 骨密度 男性 危险因素 

分 类 号：R580[医药卫生—内分泌]