护卵汤对体外受精-胚胎移植长方案干预效应的临床研究  

Long Program Intervention of Huluan Decoction on In Vitro Fertilization and Embryo Transfer

作　　者：王肖[1] 尤昭玲[2] 

机构地区：[1]郑州大学第一附属医院生殖中心,郑州450052 [2]湖南中医药大学第一附属医院妇产科,长沙410007

出　　处：《中国中西医结合杂志》2016年第7期806-809,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.81303003);湖南省研究生科研创新项目(No.CX2013B322)

摘　　要：目的研究护卵汤对行受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)患者治疗的可行性和有效性。方法将120例患者按随机数字表法分为护卵汤配合西药组(干预组,60例)和西药组(对照组,60例)。对照组采用常规的长效长方案;干预组于月经周期第3天开始同时加服护卵汤,每天1剂,连服12天。观察两组患者绒毛膜促性腺激素(human chorionic gonadotropin,HCG)注射日子宫内膜厚度、形态、内膜血流Applebaum分型、螺旋动脉血流搏动指数(pulsation index,PI)及阻力指数(resistance index,RI)、促性腺激素(gonadotropin,Gn)天数、Gn用量、获卵数、优质卵率、受精率、卵裂率、优质胚胎率、生化妊娠率、中医肾虚证候积分及疗效,以及最终对临床妊娠率及活产分娩率的影响。结果与对照组比较,干预组获卵数、优质卵率、受精率和优质胚胎率升高(P<0.05),HCG日子宫内膜厚度增加、PI及RI明显减少(P<0.01),Gn天数、Gn用量和中医证候积分减少(P<0.05),临床妊娠率及活产分娩率升高(P<0.05)。干预组内膜血流Applebaum分型优于对照组(P<0.05)。干预组总有效率为96.5%(55/57)高于对照组的80.0%(44/55),差异有统计学意义(P<0.05)。结论在IVF-ET治疗周期,应用护卵汤可明显改善患者肾虚症状,改善卵子及胚胎质量,改善子宫内膜容受性,最终提高临床妊娠率及活产率。Objective To observe the curative effect and feasibility of Huluan Decoction（HD） in assisted reproductive technique（ART） for in vitro fertilization and embryo transfer（IVF-ET） patients. Methods Totally 120 patients were assigned to the Western medicine（WM） group（60 cases, as the control） and the WM ＋ HD group（60 cases, as the intervention） according to random digit table. Patients in the control group received routine long-acting long program. Those in the intervention group additionally took HD, one dose per day for 12 successive days starting from the 3^（rd） day of the menstrual cycle. The following indicators were observed in the two groups： endometrial thickness on human chorionic gonadotropin（HCG） day, endometrial morphology, endometrial blood flow Applebaum type, spiral arteries blood flow pulsation index（PI） and resistance index（RI）, gonadotropin（Gn） days, Gn dosage, the number of retrieval eggs, the rate of high quality eggs, the fertilization rate, the cleavage rate, the high quality embryo rate, the biochemical pregnancy rate, curative effect and integral of Shen deficiency syndrome. And their effects on final pregnancy rate and liveborn birth rate were also observed. Results In the intervention group the number of retrieval eggs,the rate of high quality eggs, the fertilization rate, and the high quality embryo rate all increased（P 〈0. 05）, endometrial thickness on HCG day significantly increased, PI and RI obviously decreased（P 〈0. 01）, Gn days, Gn dosage, integral of Shen deficiency syndrome were reduced（P 〈0. 05）, clinical pregnancy rate and liveborn birth rate were alsoelevated（P 〈0. 05）, as compared with the control group. Endometrial blood flow Applebaum type was superior in the intervention group to that in the control group（P 〈0. 05）. The total effective rate was 96. 5%（55/57 cases） in the intervention group, higher than that in the control group [80. 0%（44/55 cases）; P 〈0. 05]. Conclusion In IVF-ET treatment

关 键 词：护卵汤 体外受精-胚胎移植 子宫内膜容受性 

分 类 号：R714.8[医药卫生—妇产科学]