脊髓损伤中坏死性凋亡的发生与调控机制研究现状及展望  

The role of necroptosis in spinal cord injury： current research and prospect

作　　者：郑启新[1] 田青[1] 郭晓东[1] 邓享誉 

机构地区：[1]华中科技大学同济医学院附属协和医院骨科医院,武汉430022

出　　处：《中华实验外科杂志》2016年第7期1691-1695,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81171159）

摘　　要：脊髓损伤（SCI）的修复是长期困扰临床的难题，病理变化分为原发性损伤和继发性损伤，其中SCI后缺血缺氧等原因引起的继发性神经元大面积死亡是造成病变加重的重要原因。目前，继发性神经元死亡的机制仍不明确。坏死性凋亡是一种新发现的细胞程序性坏死形式，在SCI导致的继发性神经细胞死亡和损伤后组织内炎性反应的激活中扮演重要的角色。随着对坏死性凋亡信号转导机制的深入研究及其高效特异性抑制剂（Necrostatin-1）的发现，有望为SCI的临床治疗提供新的思路。本文就SCI中坏死性凋亡的发生、调控机制和临床应用价值的研究现状及展望作一述评。Spinal cord injury （SCI） is a worldwide clinical challenge for spinal surgeons. To bet- ter understand these pathological processes, SCI has been classified into primary injury and secondary injury. The secondary injury of SCI is considered an essential fator, leading to the death of neuron. Currently, the mechanism of secondary injury is unclear. Neeroptosis, a new model of programmed cell death, plays an important role in the injury of neuron and the activation of inflammation in SCI. The deep understanding of mechanism of neeroptosis and the findings of specific inhibitors （ such as Necrostatin - 1 ） provide new ways for the treatment of SCI. Next, we reviews the advances in mechanisms and clinical translation value of necroptosis.

关 键 词：脊髓损伤 坏死性凋亡 炎性反应 

分 类 号：R651.2[医药卫生—外科学]