5,10,15,20-四(4-氨基苯基)卟啉的合成进展  

Progress in Synthesis of 5,10,15,20-Tetrakis(4-Aminophenyl) Porphyrin

作　　者：邹太和[1] 罗通[1] 罗华锋[1] 田婧 雷开键[2] 薛智[1] 

机构地区：[1]宜宾学院化学与化工学院,四川宜宾644007 [2]宜宾市第二人民医院肿瘤科,四川宜宾644000

出　　处：《宜宾学院学报》2016年第6期94-98,共5页Journal of Yibin University

基　　金：四川省教育厅资助科研项目(14ZB0280);宜宾学院重点科研资助项目(2013QD11)

摘　　要：5,10,15,20-四(4-氨基苯基)卟啉的合成主要有两大途径:一是根据传统Adler方法,以4位官能团(酰氨基,硝基,卤素)取代的苯甲醛与吡咯在酸性条件下进行缩合,所得卟啉中间体再进一步水解或还原或者氨化可得目标产物;二是由无取代的苯甲醛与吡咯缩合得到5,10,15,20-四苯基卟啉,该中间体再经外围硝化,还原得到目标产品.综合两种方法,第二类方法步骤虽多,但是原料价格便宜,操作简单,更适合大规模生产.There are two synthetic approaches of 5,10,15,20- tetrakis （4-aminophenyl） porphyrin （TAPP）. One is called Adler＇s method, in which benzaldehyde with 4-radical （4-acetamido, 4-nitro-, or 4-halogen） is converted by condensa- tion with pyrrole under acidic condition. Then the target product is obtained by hydrolysis, reduction or amination of this intermediate respectively. Another method is camed on benzaldehyde and pyrrole to gain 5,10,15,20-tetrakis-phenylpor- phyrin （TPP）. After that, TPP is nitrated and reduced to afford TAPP. Although the second method includes more steps than Adler＇s method, it involves much cheaper raw material, so it is easier to be manipulated, and is more fitful for mass production.

关 键 词：5 10 15 20-四(4-氨基苯基)卟啉 硝化 还原 水解 取代苯甲醛 

分 类 号：O621.3[理学—有机化学]