组织工程韧带的重建策略  

Construction strategies for tissue-engineered ligaments

作　　者：狄亚龙 韩长旭[2] 赵亮[1] 任逸众[2] 

机构地区：[1]内蒙古医科大学研究生学院,内蒙古自治区呼和浩特市010110 [2]内蒙古医科大学第二附属医院,内蒙古自治区呼和浩特市010030

出　　处：《中国组织工程研究》2016年第29期4368-4375,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:应用于骨科手术的肌肉骨骼生物工程和再生医学不断演变。目的:了解决组织工程的膝关节韧带重建策略。方法:在Pub Med数据库使用术语"膝关节韧带"和"组织工程"或"再生医学"完成了系统回顾。2位作者进行检索,独立评估纳入研究,并提取数据列入审查。对临床前和临床研究进行了回顾,并将认为最相关的文章列入综述,提供关于目前在膝关节韧带重建使用的"组织工程"策略的相关基础科学和近期的临床转化知识。结果与结论:对PubM ed最初检索出的224篇文章进行了分析。排除非英文文献,回顾了临床和临床前实验研究,重点专注于膝关节韧带组织工程策略的研究,包括基于干细胞的治疗、生长因子、混合生物材料和支架的发展以及力学刺激模式等。目前韧带重建组织工程技术有一些潜在的优势,包括恢复快,韧性更好和可能减少复发。这些新疗法的临床前研究提供了可喜的成果,但仍需要精心设计的高标准临床对照研究为其将来成功转化到临床提供基础。BACKGROUND：Until now, musculoskeletal bioengineering used in the orthopedic surgery and regenerative medicine are developing. OBJECTIVE：To summarize the construction strategies for tissue-engineered knee ligaments. METHODS：A computer-based online search was conducted in PubMed to screen the relevant literatures using the terms“knee ligament”AND“tissue engineering”OR“regenerative medicine”. The literature retrieval, data assessment and extraction were performed by both authors independently. The relevant literatures were included through reviewing preclinical and clinical studies to display the preclinical and clinical medicine progresses in the construction strategies for tissue-engineered ligaments. RESULTS AND CONCLUSION：Included 224 literatures focus on the construction strategies for tissue-engineered ligaments, including stem cel therapy, growth factors, biomaterials and scaffolds, and mechanical stimulation pattern. Construction techniques for tissue-engineered ligaments have some potential advantages, such as rapid function recovery, good tenacity, and reduced relapse. However, rigorous and high-level randomized control ed clinical trials are needed for the translation of preclinical results into successful clinical trials.

关 键 词：韧带 再生医学 组织工程 组织构建 细胞因子 肌腱 愈合 

分 类 号：R318[医药卫生—生物医学工程]