脱细胞真皮基质膜引导骨缺损成骨变化（英文）  

Guided bone regeneration with acellular dermal matrix as a barrier for bone defects

作　　者：贾仁杰[1] 任玉卿 徐昊[2] 王维英[2] 弋中萍 赵保东[2] 

机构地区：[1]青岛大学,山东省青岛市266000 [2]青岛大学附属医院口腔种植中心,山东省青岛市266100

出　　处：《中国组织工程研究》2016年第30期4442-4448,共7页Chinese Journal of Tissue Engineering Research

基　　金：the Natural Science Foundation of Shandong Province,China,No.ZR2010HM036~~

摘　　要：背景:脱细胞真皮基质膜具有良好的生物相容性、可吸收性、引导骨再生性能。目的:比较脱细胞真皮基质膜和BioGide膜引导骨缺损成骨的组织学变化及引导骨再生的效果的差异。方法:12只比格犬拔除双侧下颌骨第二、三、四前磨牙及第一磨牙3个月后,在每只犬的下颌骨各建立4处标准的三壁骨缺损模型,随机分为脱细胞真皮基质膜联合骨修复材料组、Bio-Gide膜联合骨修复材料组、骨修复材料组、空白对照组。除空白对照组不做任何处理外,将骨修复材料充实于其余3组骨缺损处。脱细胞真皮基质膜联合骨修复材料组和Bio-Gide膜联合骨修复材料组分别将脱细胞真皮基质膜和Bio-Gide膜覆于骨缺损处的骨修复材料上。结果与结论:术后Begale犬状况均良好。与空白对照组相比,其他3组骨缺损处组织学情况明显改善,新生骨组织面积百分比明显上升,且Bio-Gide联合骨修复材料组和脱细胞真皮基质膜联合骨修复材料组骨缺损处组织学情况及新生骨组织面积百分比明显优于空白对照组,而Bio-Gide联合骨修复材料组和脱细胞真皮基质膜联合骨修复材料组骨缺损处组织学情况及新生骨组织面积百分比接近。提示在比格犬下颌骨缺损模型中,脱细胞真皮基质膜修复的效果与临床广泛使用的Bio-Gide膜接近,因而可以替代后者。BACKGROUND： Acetlular dermal matrix has good biocompatibility and absorbability and exhibits superiority in the guided bone regeneration. OBJECTIVE： To compare the histological changes and osteogenic effects in bone defects after guided bone regeneration with acellular dermal matrix and Bio-Gide membrane. METHODS： Mandibular second, third and fourth premolars and the first molars bilaterally were extracted from 12 beagle dogs. Three months later, four three-wall bone defect models in the mandible of each dog were made, and randomized into acellular dermal matrix plus bone graft group （acellular dermal matrix group）, Bio-Gide plus bone graft group （Bio-Gide group）, bone graft group, and blank control group （no treatment）. In the former two groups, acetlular dermal matrix and Bio-Gide were used to cover the bone grafts, respectively. RESULTS AND CONCLUSION： After surgery, all the beagle dogs recovered well. All the groups except the control group showed dramatical improvement in histological changes and percentage of new bone area, and this improvement was more significant in the Bio-Gide and acellular dermal matrix groups. Moreover, there was no significant difference between the Bio-Gide and acellular dermal matrix groups. Therefore, the acellular dermal matrix can be a candidate for bone repair instead of Bio-Gide membrane in the clinical practice.

关 键 词：生物膜 骨再生 组织工程 生物材料 骨生物材料 骨缺损 脱细胞真皮基质膜 BIO-GIDE膜 比格犬 山东省自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]