钛合金内固定材料修复脊柱结核:生物相容性及力学性能  

Implant fixation with titanium alloy repairs spinal tuberculosis: its biocompatibility and mechanical properties

作　　者：庄勇[1] 尚显文[1] 张皓[1] 刘淼[1] 许顺恩[1] 

机构地区：[1]贵州医科大学附属医院骨科,贵州省贵阳市550001

出　　处：《中国组织工程研究》2016年第30期4509-4514,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:目前,对于脊柱结核主要以内固定治疗为主,但选择何种内固定材料尚存在较大的争议。目的:比较钛合金和不锈钢内固定材料修复家兔脊柱结核的生物相容性及力学性能。方法:取30只家兔,建立家兔脊柱结核模型,随机分为2组,每组15只,分别置入不锈钢材料、钛合金材料进行内固定修复。置入30 d后,观察两组生物相容性,检测脊柱修复部位生物力学性能。结果与结论:(1)生物相容性:钛合金内组未出现感染、免疫排斥等不良反应,不锈钢组3例家兔出现感染;(2)生物力学:钛合金组加载后前屈、后伸及侧弯距离显著小于不锈钢组(P<0.05),前屈、后伸、侧弯位移量显著少于不锈钢组(P<0.05),最大轴向拔出力显著大于不锈钢组(P<0.05),前屈、后伸、侧弯及轴向压缩显著大于不锈钢组(P<0.05);(3)结果表明:钛合金内固定材料具有良好的生物相容性,能够恢复和维持脊柱稳定性。BACKGROUND： Currently, surgical implant fixation is mainly applied for spinal tuberculosis. How to choose implant materials, however, is still under discussion.OBJECTIVE： To compare the biocompatibility and mechanical properties of titanium alloy and stainless steel for rabbit spinal tuberculosis. METHODS： Thirty rabbits were chosen to prepare spinal tuberculosis models. Then, the rabbits were equivalently randomized into two groups, which underwent implant fixation with stainless steel or titanium alloy, respectively. At 30 days after implantation, biocompatibility and biomechanical properties of the two materials in the repaired region of spine were observed and detected, respectively. RESULTS AND CONCLUSION： In view of the biocompatibility, infection and immunological rejection could not been found in the titanium alloy group; in contrast, infection appeared in three rabbits of the stainless steel group. Flexion, extension and lateral bending displacements under the spinal loading in the titanium alloy group were significantly less than those in the stainless steel group （P 〈 0.05）; axial pull-out strength in the titanium alloy group was significantly higher than that in the stainless steel group （P 〈 0.05）; flexion, extension, lateral bending and axial compression in the titanium alloy group were significantly greater than those in the stainless steel group （P 〈 0.05）. In conclusion, titanium alloy material has good biocompatibility that can be used to restore and maintain the spinal stability.

关 键 词：结核 脊柱 不锈钢 生物力学 组织工程 生物材料 骨生物材料 钛合金 不锈钢内固定材料 脊柱结核 生物相容性 力学性能 轴向拔出力 稳定性 

分 类 号：R318[医药卫生—生物医学工程]