功能型骨组织工程支架修复结核性骨缺损  

Functional bone tissue engineering scaffold used to repair tuberculosis bone defect

作　　者：孙效虎 袁景 张宇 乔永杰[3] 曹雪飞[3] 孟磊 高展望 甄平[3] 

机构地区：[1]庆阳市人民医院骨二科,甘肃省庆阳市745000 [2]甘肃省第二人民医院骨科,甘肃省兰州市730000 [3]解放军兰州军区兰州总医院全军骨科中心,甘肃省兰州市730050

出　　处：《中国组织工程研究》2016年第30期4539-4546,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81371983):多孔β-TCP负载聚乳酸羟基乙酸共聚物抗结核药物缓释微球的构建及其抗结核成骨作用研究~~

摘　　要：背景:随着抗结核功能型骨组织工程支架研究的深入,结核性骨缺损修复成为当前研究热点之一。目的:评价抗结核功能型骨组织工程支架的制备、药物缓释性能和成骨性能。方法:应用计算机检索Pub Med数据库、中国期刊全文数据库、万方数据库中,相关功能型骨组织工程支架修复结核性骨缺损的文章,中文检索词为"骨组织工程支架,结核,骨缺损",英文检索词为"Bone tissue engineering scaffold,Tuberculosis,Bone defect"。结果与结论:抗结核功能型骨组织工程支架具有较好的药物缓释性能、组织相容性、成骨性能及抗结核杆菌性能,能长时间稳定释放药物,增强局部应用抗结核药的效果,解决临床上结核性骨缺损修复困难易复发的难题。目前,研制的抗结核性骨组织工程支架还未达到临床需求。首先,针对结核分枝杆菌的多药物联合治疗常需3或4种抗结核药物的联合使用,而目前抗结核性骨组织工程支架只能达到联合2种药物;其次,抗结核治疗疗程常需6-12个月,现有的抗结核性骨组织工程支架药物释放时还不能满足该需求;制备抗结核性骨组织工程支架材料的文献居多,但应用此种材料在结核动物模型进行的验证实验缺失。关键词:BACKGROUND： Repairing tuberculosis bone defect has become a research focus with the development of anti-tuberculosis functional bone tissue engineering scaffold. OBJECTIVE： To evaluate the preparation, drug release performance and osteogenic properties of the anti-tuberculosis functional bone tissue engineering scaffold. METHODS： PubMed, Chinese Journal Full-text Database, Wanfang databases were searched by computer for articles addressing functional bone tissue engineering scaffold for repair of tuberculosis bone defect. The keywords were ＂bone tissue engineering scaffold; tuberculosis; bone defect＂ in English and Chinese. RESULTS AND CONCLUSION： The anti-tuberculosis functional bone tissue engineering scaffold has good drug delivery, biocompatibility, osteogenic properties and anti-tuberculosis properties. As a good choice to avert bone defect relapse, the scaffold enables a long and stable drug release into bone defects to enhance the therapeutic efficacy of anti-tuberculosis drugs topically. Given the technical deficiencies, we can only combine two drugs with the anti-tuberculosis bone tissue engineering scaffold, although the combined use of three or four anti-tuberculosis drugs is preferred. Additionally, a complete course of anti-tuberculosis treatment often lasts for 6-12 months, which cannot be achieved by the existing anti-tuberculosis bone tissue engineering scaffold. Up to now, the effect of this scaffold has not yet been confirmed in animal models, although how to prepare this scaffold has been reported.

关 键 词：结核 骨关节 支架(骨科) 组织工程 生物材料 缓释材料 骨组织工程支架 骨结核 骨缺损 功能型 结核性骨缺损 修复 制备 缓释系统 成骨性能 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]