六味补血胶囊的16组拆方对环磷酰胺所致血虚小鼠造血功能的影响  被引量:5

Impact of 16 demolition groups of six kinds of Buxue capsule on hematopoietic function of blood deficiency mice resulted from cyclophos-phamide

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作  者:鲁艺 肖丽和 杜晓娟 宋茜 王淑红 王平 王铁杰 

机构地区:[1]深圳市药品检验研究院,深圳518057

出  处:《中国当代医药》2016年第18期12-14,18,共4页China Modern Medicine

基  金:广东省深圳市科技计划项目(JCYJ 20140722104416530)

摘  要:目的 探讨六味补血胶囊的16组拆方对血虚小鼠造血功能的影响。方法 将健康NIH雄性小鼠190只随机分为19组,分为阳性组、空白组、模型组、拆方组(拆方1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16组),每组10只。腹腔注射环磷酰胺制作化学药物诱发血虚证小鼠模型。阳性组给予复方阿胶浆,每次0.3 ml/20 g;空白组和模型组给予生理盐水,每次0.3 ml/20 g;拆方1-16组小鼠按相应配伍剂量连续灌胃28 d,1次/d,每次0.3 ml/20 g。观察各组对血虚小鼠外周血象等指标的影响。结果 血红蛋白、红细胞、网织红细胞各指标模型组均值低于空白组,(P〈0.01),模型组与空白组有显著差异,表明造模成功,全方组(拆方16组)高于其他拆方组和阳性组。结论 六味补血胶囊对环磷酰胺造成的血虚小鼠造血功能改善明显,其配伍具有合理性。Objective To explore the impact of 16 demolition groups of six kinds of Buxue capsule on hematopoietic function of blood deficiency mice.Methods 190 health NIH male mice were divided into nineteen groups,namely positive group,black group,mode group,demolition groups(including demolition group 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16),with each group 10 mice.Intraperitoneal injection cyclophosphamide was used to duplicate blood deficiency mice model.Positive group was given compound E Jiao Jiang(0.3 ml/20 g each time);Blank group and model group was given normal saline(0.3 ml/20 g each time);The rest of the 16 groups according to the corresponding dose lavage 28 days(1 time/d,0.3 ml/20 g each time).The impact of each group on the peripheral blood indicators of blood deficiency mice was observed.Results The mean value of hemoglobin,red blood cell and reticulated red blood cell in mode group were lower than those in black group(P〈0.01),and the difference between mode group and black group was obvious,which showed that the model was successful;The whole prescription group(demolition group 16) was higher than other demolition groups and positive group.Conclusion Six kinds of Buxue capsule has obvious improvement in hematopoietic function of blood deficiency mice that resulted from cyclophosphamide,which compatibility of medicines is rational.

关 键 词:六味补血胶囊 外周血象 血虚小鼠 环磷酰胺 

分 类 号:R932[医药卫生—生药学]

 

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