Ferritin surplus in mouse spleen 14 months after intravenous injection of iron oxide nanoparticles at clinical dose  

作　　者：Alexandre Tamion Matthias Hillenkamp Arnaud Hillion Valentin A. Maraloiu Ioana D. Vlaicu Mariana Stefan Daniela Ghica Hugo Rositi Fabien Chauveau Marie-Genevieve Blanchin Marlene Wiart Veronique Dupuis 

机构地区：[1]Institut Lumiere Matiere, UMR5306 Universite Lyon 1- CNRS, Universite de Lyon, 69622 Villeurbanne cedex, France [2]National Institute of Materials Physics, 105bis AtomistilorSt., R-077125 Bucharest-Magurele, Romania [3]CNRS, UMR 5220, INSERM, U1044, INSA de Lyon, Universite de Lyon, Lyon 1, CREATIS, 69003 Lyon, France [4]CRNL-BIORAN, CNRS UMR5292, INSERM U 1028, Universite Lyon 1, 59 BD PINEL, 69677, Bron, France

出　　处：《Nano Research》2016年第8期2398-2410,共13页纳米研究（英文版）

摘　　要：In this study, we followed the biodegradation of ultra-small superparamagnetic iron oxide nanoparticles injected intravenously at clinical doses in mice. An advanced fitting procedure for magnetic susceptibility curves and low- temperature hysteresis loops was used to fully characterize the magnetic size distribution as well as the magnetic anisotropy energy of the injected P904 nano- particles （Guerbet Laboratory）. Additional magnetometry measurements and transmission electronic microscopy observations were systematically performed to examine dehydrated samples from the spleen and liver of healthy C57B16 mice after nanoparticle injection, with sacrifice of the mice for up to 14 months. At 3 months after injection, the magnetic properties of the spleen and liver were dramatically different. While the liver showed no magnetic signals other than those also present in the reference species, the spleen showed an increased magnetic signal attributed to ferritin. This surplus of ferritin remained constant up to 14 months after injection.In this study, we followed the biodegradation of ultra-small superparamagnetic iron oxide nanoparticles injected intravenously at clinical doses in mice. An advanced fitting procedure for magnetic susceptibility curves and low- temperature hysteresis loops was used to fully characterize the magnetic size distribution as well as the magnetic anisotropy energy of the injected P904 nano- particles （Guerbet Laboratory）. Additional magnetometry measurements and transmission electronic microscopy observations were systematically performed to examine dehydrated samples from the spleen and liver of healthy C57B16 mice after nanoparticle injection, with sacrifice of the mice for up to 14 months. At 3 months after injection, the magnetic properties of the spleen and liver were dramatically different. While the liver showed no magnetic signals other than those also present in the reference species, the spleen showed an increased magnetic signal attributed to ferritin. This surplus of ferritin remained constant up to 14 months after injection.

关 键 词：nanoparticles BIODEGRADATION iron oxide NANOMAGNETISM contrast agent 

分 类 号：O[理学]