Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation  

作　　者：Meng Li Yijia Guan Zhaowei Chen Nan Gao Jinsong Ren Kai Dong Xiaogang Qu 

机构地区：[1]Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, China [2]University of Chinese Academy of Sciences, Beijing 100039, China

出　　处：《Nano Research》2016年第8期2411-2423,共13页纳米研究（英文版）

基　　金：This work was supported by the National Basic Research Program of China （Nos. 2012CB720602 and 2011CB936004）, and the National Natural Science Foundation of China （Nos. 21210002, 21431007, and 21533008）.

摘　　要：Amyloid β-peptide （Aβ） aggregation is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of A[3 production, dissolution of existing aggregates and clearance of Aβ represent valid therapeutic strategies against AD. Herein, a novel platinum（II）-coordinated graphitic carbon nitride （g-C3N4） nanosheet （g-C3N4@Pt） has been designed to covalently bind to Aβ and modulate the peptide＇s aggregation and toxicity. Furthermore, g-CBN4@Pt nanosheets possess high photocatalytic activity and can oxygenate Aβ upon visible light irradiation, remarkably attenuating both the aggregation potency and neurotoxicity of Aβ Due to its ability to cross the blood-brain barrier （BBB） and its good biocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of Aβ aggregation. This study may serve as a model for the engineering of novel multifunctional nanomaterials used for the treatment of AD.Amyloid β-peptide （Aβ） aggregation is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of A[3 production, dissolution of existing aggregates and clearance of Aβ represent valid therapeutic strategies against AD. Herein, a novel platinum（II）-coordinated graphitic carbon nitride （g-C3N4） nanosheet （g-C3N4@Pt） has been designed to covalently bind to Aβ and modulate the peptide＇s aggregation and toxicity. Furthermore, g-CBN4@Pt nanosheets possess high photocatalytic activity and can oxygenate Aβ upon visible light irradiation, remarkably attenuating both the aggregation potency and neurotoxicity of Aβ Due to its ability to cross the blood-brain barrier （BBB） and its good biocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of Aβ aggregation. This study may serve as a model for the engineering of novel multifunctional nanomaterials used for the treatment of AD.

关 键 词：amyloid disease PLATINUM graphitic carbon nitridenanosheet PHOTOOXYGENATION amyloid β-peptide （Aβ）inhibitors 

分 类 号：O[理学]