2013-2015年浙江地区新型甲型H1N1流行性感冒的流行病学和临床特征调查  

Investigation of clinical characteristics and epidemiology of novel influenza A(H1N1) infection in Zhejiang province from 2013 to 2015

作　　者：车飞虎[1,2,3] 崔大伟[1,2] 孙海燕[1,2] 高敏[1,2] 杨先知[1,2] 谢国良[1,2] 陈瑜[1,2] 

机构地区：[1]浙江大学医学院附属第一医院检验科,杭州310003 [2]浙江省临床体外诊断技术研究重点实验室,杭州310003 [3]中国人民解放军第117医院检验科,杭州310013

出　　处：《临床检验杂志》2016年第4期307-311,共5页Chinese Journal of Clinical Laboratory Science

基　　金：国家科技重大专项(2012ZX10004-210);浙江省医药卫生科技项目(2015KYB149)

摘　　要：目的调查2013-2015年浙江地区哨点医院监测的新型甲型H1N1流行性感冒(简称流感)的临床特征及其流行病学特征。方法对2013-2015年浙江地区8家哨点医院纳入的符合急性呼吸道感染的患者进行流行病学和临床特征调查,采集研究对象呼吸道标本进行流感病毒检测,分析新型甲型H1N1流感病毒阳性组与阴性组的临床和流行病学特征。结果 8家哨点医院共纳入7 602例急性呼吸道感染患者,其中,实验室确诊新型甲型H1N1流感779例(10.2%),新型甲型H1N1流感患者中位年龄为51岁,115例(33.6%)患有至少1种慢性基础性疾病,新型甲型H1N1流感中哮喘比例(2.6%)高于流感病毒阴性患者(0.6%),差异有统计学意义(χ2=12.706,P<0.01)。新型甲型H1N1流感中恶心、呕吐所占比例高于流感病毒阴性患者,排痰性咳嗽、腹泻所占比例低于流感病毒阴性患者。新型甲型H1N1流感患者的白细胞计数和中性粒细胞计数均低于流感病毒阴性组,差异均有统计学意义(P<0.05)。结论浙江地区人感染新型甲型H1N1流感的高发期为每年的冬春季节,其他时间呈散发。新型甲型H1N1流感的临床症状与非流感患者相比较无特异表现。Objective To investigate the clinical and epidemiological characteristics of human infections with the novel influenza A（ H1N1） monitored by the sentinel surveillance system in Zhejiang province from 2013 to 2015. Methods The epidemiological characteristics and clinical data of the cases with acute respiratory were monitored in eight sentinel hospitals of Zhejiang province from 2013 to2015. The specimens from respiratory tract were detected for the novel influenza A（ H1N1） virus. The acute respiratory cases were classified into H1N1-positive or negative group and their clinical and epidemiological characteristics were analyzed. Results A toyal of7602 cases with acute respiratory infections were recruited from eight sentinel hospitals,including 779 cases（ 10. 2%） of laboratoryconfirmed novel influenza A（ H1N1） with average age of 51 year old,115 cases（ 33. 6%） of H1N1 infectors suffered from at least one chronic underlying disease. The proportion of concomitant asthma（ 2. 6%） of the H1N1 infectors was higher than that of the influenzanegative patients（ 0. 6%） with statistically significant difference（ χ^2= 12. 706,P〈0. 01）. The proportion of nausea or vomiting of the H1N1 infectors was higher than that of the influenza-negative patients,while the proportion of cough or diarrhea was lower than that of the influenza-negative patients. The count of white blood cell and neutrophil of the H1N1 infectors were lower than that of the influenzanegative patients. Conclusion The outbreaks of H1N1 virus infection usually occurred in winter and spring in Zhejiang province,and in other seasons only sporadic cases were reported. The clinical symptoms of H1N1 influenza patients showed no specific manifestations.

关 键 词：新型甲型H1N1流感病毒 流行病学 临床特征 监测 

分 类 号：R446[医药卫生—诊断学]