口服补液盐[I]治疗神经介导性晕厥儿童血清及尿电解质的变化  被引量:7

Changes in serum and urine electrolytes of children with neurally mediated syncope after oral rehydration salts [I] treatment

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作  者:张文华[1] 王成[1] 许毅[1] 邹润梅[1] 吴礼嘉[1] 罗雪梅[1] 林萍[1] 李芳[1] 

机构地区:[1]中南大学湘雅二医院儿童医学中心儿童心血管专科,中南大学儿科学研究所,长沙410011

出  处:《中华实用儿科临床杂志》2016年第13期978-981,共4页Chinese Journal of Applied Clinical Pediatrics

基  金:湖南省发改委课题[湘财企指(2015)83];湖南省自然科学基金(2016JJ2167)

摘  要:目的探讨神经介导性晕厥(NMS)儿童应用口服补液盐(ORS)[I]治疗前后血清及尿电解质的变化。方法2014年5月至2015年4月因不明原因晕厥及晕厥先兆等症状在中南大学湘雅二医院儿童晕厥专科门诊就诊或住院的患儿135例。男60例,女75例;年龄4~16(10.20±2.68)岁。完成直立倾斜试验(HuTr),同时完善血清和24h尿电解质检查,比较HUTT不同血流动力学类型患儿血清和24h尿电解质。HuTT阳性者予健康教育和ORS[I]治疗,HUTT阴性者仅予健康教育。21~154(42.63±27.71)d后来院复诊,询问症状改善情况,复查HUTT及血清、24h尿电解质。结果1.ORS[I]治疗总有效率为62.96%(17/27例),HUTT转阴率为48.15%(13/27例)。2.初诊HUTT阳性组与HUTT阴性组在血清电解质、24h尿电解质及24h尿量比较,差异均无统计学意义(P均〉0.05)。3.复诊Hu,IvI、阳性组较HUTT阴性组在血清钙[(2.30±0.10)mmol/L比(2.20±0.09)mmol/L,t=2.72,P〈0.05]、血清磷[(1.73±0.22)mmol/L比(1.51±0.23)mmol/L,t=2.671,P〈0.05]增加,在血清钠、钾、氯、镁及24h尿电解质、24h尿量的差异均无统计学意义(P均〉0.05)。4.ORS[I]治疗后24h尿钠[(159.06±72.76)mmo]/24h比(118.97±52.75)mmol/24h,t=2.712,P〈0.05l、24h尿氯l(139.08±66.53)mmol/24h比(111.34±47.33)mmol/24h.t=2.116,P〈0.05]及24h尿量[(1564.21±829.39)mL比(1058.95±509.92)mL,f=3.371,P〈0.01]较治疗前明显增加,差异有统计学意义;血清电解质及24h尿钾、钙、磷、镁治疗前后的差异均无统计学意义(P均〉0.05)。5.初诊HUTT阳性的血管迷走性晕厥组和体位性心动过速综合征组在血清、尿电解质比较,差异均无统计学意义(P均〉0.05)。结论ORS[I]治疗后能明显增加NMS儿童24h尿钠、尿氯,为治疗NObjective To explore the changes in serum and urine electrolytes of children with neurally media- ted syncope (NMS) after oral rehydration salts (ORS) [I] treatment. Methods The study group included 135 patients [60 male and 75 female,aged 4-16 years,average of (10.20 ±2.68) years old] with unexplained syncope and prodro- mal symptoms of syncope in our hospital between May 2014 and April 2015. The patients underwent head - up tilt test (HUTT) ,and completed serum electrolytes and 24 -hour urine electrolytes ,and the serum electrolytes and 24 -hour u- rine electrolytes in different hemodynamic type of HUTY were compared. Positive HUTF patients were treated with health education and ORS[l] ,while negative HUT]" patients were received health education. Then 21 - 154 (42.63 ± 27.71 ) days later, the patients returned to hospital ,for the inquiry of symptom improvement, and review of HUTY ,24 -hour urine and serum electrolytes. Results ( 1 ) The total effective rate of ORS [ I] treatment was 62.96% ( 17/27 cases), while negative conversion rate of HUTT was 48.15% (13/27 cases). (2)There was no significant difference in serum electro- lytes ,24 - hour urine electrolytes or 24 - hour urine volume between HUTY positive group and negative group during the first visit (all P 〉 0.05 ). (3)In return visit, serum calcium [ (2.30± 0.10) mmol/L vs (2.20 ± 0.09 ) mmol/L, t = 2. 72, P 〈 0.05 ] and serum phosphorus [ ( 1.73 ± 0.22 ) mmol/L vs ( 1.51 ±0.23 ) mmol/L, t = 2.671, P 〈 0. 05 ] in HUTT positive group were significantly higher than those in negative group. The serum sodium, potassium, chloride, mag- nesium and 24 -hour urine electrolytes ,24 -hour urine volume had no statistical difference (all P 〉 0.05 ). (4)24 -hour urine sodium [ (159.06 ±72.76) mmol/24 h vs (118.97 ±52.75) mmoL/24 h,t =2.712,P 〈0.05] ,24 -hour urine chloride [ (139.08 ±66.53) mmol/24 h vs ( 111.34 ±47.33) mmol/24 h,t =2. 116,P 〈0.05] and 24 - ho

关 键 词:神经介导性晕厥 口服补液盐 儿童 电解质 24 h尿电解质 

分 类 号:R725.4[医药卫生—儿科]

 

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