肺动脉平滑肌细胞增殖相关因子与肺动脉高压  

Relevant factors of pulmonary arterial smooth muscle cells proliferation and pulmonary arterial hypertension

作　　者：张锋[1] 庞玉生[1] 劳金泉[1] 

机构地区：[1]广西医科大学第一附属医院儿科,南宁530021

出　　处：《中华实用儿科临床杂志》2016年第13期1031-1033,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金（81160040）;广西自然科学基金（2013GXNSFAA019177）

摘　　要：肺动脉高压是一不明原因导致的肺血管阻力不断增加的疾病，若未经治疗，最终导致右心衰竭和高病死率。肺血管收缩和血管重塑被认为是导致肺动脉高压的2个主要病理生理变化，特别是肺动脉平滑肌细胞的增殖起了重要的作用。研究表明许多相关因子参与肺动脉平滑肌细胞增殖的调控，从而导致肺动脉高压的发生。Pulmonary arterial hypertension （PAH） is a disease of unknown etiology that leads to a progressive increase in pulmonary vascular resistance （ PVR）, if untreated, ultimately fight heart failure and high mortality. It is concerted pulmonary vascular contraction and vascular remodeling are the 2 main courses of physiology and pathology leading to PAH, especially the significant role of proliferation of pulmonary arterial smooth muscle cells. A lot of relevant factors are revealed to take a participation into regulating the proliferation of pulmonary arterial smooth muscle cells and finally PAH.

关 键 词：肺动脉平滑肌细胞 细胞增殖 相关因子 肺动脉高压 

分 类 号：R544.1[医药卫生—心血管疾病]