氨甲环酸对初次单侧全膝关节置换术失血量的影响  

作　　者：钟滢[1] 朱星瑜[2] 吴立东[3] 

机构地区：[1]浙江中医药大学附属第一医院,310006 [2]浙江中医药大学,310053 [3]浙江大学医学院附属第二医院,310009

出　　处：《浙江临床医学》2016年第8期1417-1418,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨全膝关节置换术中应用氨甲环酸对失血量的影响。方法回顾性研究初次单侧全膝关节置换病例，根据氨甲环酸不同的使用方式分为静脉组、局部加静脉联合组和对照组。分析患者失血量和术后血栓栓塞事件。结果联合组较对照组在总红细胞丢失量、显性红细胞丢失量和隐性红细胞丢失量上均显著降低。静脉组较对照组在总红细胞丢失量和隐性红细胞丢失量上显著降低。结论氨甲环酸能显著降低全膝关节置换术失血量且不增加术后血栓栓塞事件风险。Objective To investigate the safety and efficiency of tranexamic acid （ TXA ） to reduce blood loss in primary total knee arthroplasty （ TKA ） . Methods Retrospectively reviewed 134 patients underwent total knee arthroplasty. Patients were divided into three groups： control group, intravenous （ IV ） group and combination group. Then the blood loss and complications of each group were compared. Results Compared with control group, total RBC loss, hidden RBC loss in IV group and combination group were significant reduced. Conclusions Application of tranexamic acid may reduce blood loss in patients undergoing primary total knee arthroplasty, without increasing the risk of deep vein thrombosis and pulmonary embolism.

关 键 词：全膝关节置换 氨甲环酸 失血量 深静脉血栓形成 

分 类 号：R687.4[医药卫生—骨科学]