地佐辛与芬太尼联合丙泊酚在无痛胃肠镜检查中应用的比较  

作　　者：王宝宁[1] 李青波[1] 汪江[1] 赵琳[1] 徐学武[1] 方伟武[1] 

机构地区：[1]北京中国人民解放军第306医院麻醉科,100101

出　　处：《浙江临床医学》2016年第8期1522-1523,共2页Zhejiang Clinical Medical Journal

摘　　要：目的比较地佐辛与芬太尼在无痛胃肠镜检查术中应用的效果。方法选择行无痛胃肠镜检查的患者400例，随机分为地佐辛组（DP组，试验组）和芬太尼组（FP组，对照组），每组各200例。DP组患者静脉注射地佐辛5mg，FP组患者静脉注射芬太尼50μg。药物注射lmin后，静脉注射丙泊酚2—2．5mg/kg实施麻醉。观察记录各纽丙泊酚总用量、起效时间、苏醒时间、术中心率（HR）、平均动脉压（MAP）和血氧饱和度（SpO2）、术中有无体动、呼吸抑制、术后有无恶心呕吐、术后镇静评分等。结果DP组患者的HR、MAP、SpO2的变化趋势与FP组患者的变化趋势相近，且两组患者间差异无统计学意义（P〉0．05）；两种联合用药方案所达到的麻醉起效时间无明显差异，但DP组患者的苏醒时间较FP组患者短；DP组的不良反应总体优于FP组，DP组患者的呼吸抑制和术后镇静评分均优于FP组。结论地佐辛联合丙泊酚能够较好地应用于无痛胃肠镜的检查，且具有麻醉效果确切，呼吸抑制发生率低，苏醒时清醒程度高等优点。Objective To compare the effects of dezocine and fentanyl combined with propofol in painless gastrointestinal endoscopy. Methods Four hundred patients, scheduled for painless gastrointestinal endoscopy in our hospital, were rolled in this study. According to random serial numbers, all subjects were divided into two groups： dezocine group （ DP group, namely trial group ） and fentanyl group （ FP group, namely control group ） , 200 patients each. The patients in the trial group were intravenously administered dezocine 5mg and those patients in control group got fentanyl 50 μg intravenously lmin before the anesthesia induction, which was made by intravenous propofol 2-2.5 mg/kg. During the procedure, the follows were recorded, such as the total dose ofpropofol, the effective time, recover time, HR, MAP, SpO2, adverse effects （ body movement, respiratory inhibition, vomit＆nausea postoperation ） and Ramsay score postoperation. Results The change trend of HR, MAP, SpO2 in DP group was similar to that in FP group and there was no significant difference between them （ P〉0.05 ） . The onset time of DP combination is similar to that of FP combination, but the recover time of DP group is shorter than that of FP group. The overall situation in DP is better than that in FP group. The incidence of respiratory inhibition and Ramsay score of DP patients are better that those of FP patients. Conclusions The combined medication of dezocine and propofol could be safe and effective for patients in gastrointestinal endoscopy with advantages of effective anesthesia, lower incidence of respiratiroy inhibition and better recovery.

关 键 词：地佐辛 芬太尼 丙泊酚无痛 胃肠镜检查术 

分 类 号：R656[医药卫生—外科学]