氘代药物进展  

Deuterated Drugs Progress

作　　者：刘洁[1] 

机构地区：[1]临沂大学化学化工学院,山东临沂276000

出　　处：《化工设计通讯》2016年第4期199-199,238,共2页Chemical Engineering Design Communications

摘　　要：简要地介绍了氘的动力学同位素效应,以及将药物分子中特定的氢替换成氘得到的氘代药物,可以改变药物在体内的代谢速度甚至是代谢途径,达到增加药效和减少副作用的目的。同时还介绍了氘代药物的研究进展和临床情况。尽管到目前为止还没有一个氘代药物被批准上市,但是其临床中表现出的治疗效果还是显著的,相信在不久的未来氘代药物的上市会得到实现。Briefl y describes deuterium kinetic isotope effect,and the deuterated drugs obtained by replacing specifi c hydrogen into deuterium.The deuterated drugs can alternate the rate of metabolism and even metabolic pathways in vivo,so they may improve pharmacokinetics and reduce side effects.It also introduced the research and clinical progress of deuterated drugs.Although there is not a deuterated drug is approved for marketing so far,some deuterated drugs＇ clinical therapeutic effect exhibits signifi cantly,in the near future deuterated drugs marketing will be achieved.

关 键 词：氘代药物 动力学同位素效应 代谢 临床 

分 类 号：R96[医药卫生—药理学]