人类长寿相关基因的遗传学研究进展  

Progress on aging and longevity-associated genes in humans

作　　者：李宁[1] 罗怀超 张广健[3] 李秀兰[1] 张丁丁[4] 

机构地区：[1]遵义医学院免疫学教研室,贵州遵义563099 [2]西南医科大学临床医学院,四川泸州646000 [3]泰山医学院附属医院,山东泰安271000 [4]四川省人民医院健康管理中心,四川成都610000

出　　处：《遵义医学院学报》2016年第3期326-332,共7页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81470667)

摘　　要：人类长寿是个体的遗传背景和环境因素联合作用的结果。作为一种复杂的生物学现象,长寿相关的信号通路和基因较多。随着二代测序技术的广泛运用,三代测序技术的研究开发,一系列长寿相关基因被人们所认知,例如:胰岛素\胰岛素样生长因子-1信号通路相关基因、脂代谢信号通路相关基因、端粒酶基因、抗炎症因子基因、肿瘤抑制基因、氧化应激损伤基因等。对长寿基因的研究将加深人们对衰老的认识,促进对增龄相关疾病病理机制的研究。本文就长寿相关基因最新研究进展进行综述。Human longevity is known to be the result of combinations of the genetic background and environmental factors.As a complex biological phenomenon,longevity is related to many metabolic signaling pathways and genes.With the widespread application of the second generation sequencing technology and the development of the third generation sequencing technology,a series of longevity related genes were known.For example,the genes related to the insulin/IGF-1 signaling（IIS） pathway,the genes related to lipoprotein metabolic signaling pathway,anti-inflammatory factor genes,proinflammatory factor genes,tumor suppressor oncogenes,telomerase genes,oxidative stress injury genes,et al.Thus,the research for the longevity genes could promote the understanding of the human aging and the study for pathogenesis of age-related diseases in the future.This article reviews the latest progress on the longevity-associated genes.

关 键 词：人类长寿 长寿相关基因 衰老 单核苷酸多态性 

分 类 号：Q987[生物学—遗传学]