免疫抑制治疗儿童再生障碍性贫血疗效观察  

Efficacy of Immunosuppressive Therapy in Children With Aplastic Anemia

作　　者：赵小强[1] 岳晶晶[1] 阮林海[1] 

机构地区：[1]河南科技大学临床医学院、河南科技大学第一附属医院血液内科,河南洛阳471003

出　　处：《中国继续医学教育》2016年第17期132-134,共3页China Continuing Medical Education

摘　　要：目的探讨抗胸腺细胞球蛋白(ATG)联合环胞素A的疗效及安全性。方法选取AA患儿70例,随机分为单纯Cs A组和ATG+Cs A组,各35例。单纯Cs A组仅采用Cs A治疗,ATG+Cs A组在单纯Cs A基础上用ATG治疗。比较两组患者的临床疗效、不良反应及生存情况。结果 ATG+Cs A组基本痊愈率、总有效率明显高于单纯Cs A组,差异有统计学意义(P<0.05)。ATG+Cs A组所有患者有不良反应发生,血清病反应15例,治疗期间感染率为60%,均对症处理后好转。ATG+Cs A组与单纯Cs A组的1年、3年、5年生存率无统计学差异(P>0.05)。结论 ATG联合Cs A治疗具有起效快、反应率高等优势,且不良反应可耐受,对于那些无完全符合骨髓供应,出血和感染风险高的患儿是一种有效的治疗方法。Objective To investigate the efficacy and safety of anti-thymus globulin（ATG） combined with cyclosporin A.Methods 70 cases of children with AA were randomly divided into two groups,35 cases in each group： Simple Cs A group and ATG＋Cs A group.Simple Cs A group was treated only with Cs A,and the ATG＋Cs A group,on the basis of Cs A alone,was treated with ATG,to compare the clinical efficacy,adverse reaction and survival of two groups.Results The basic cure rate and total effective rate of ATG＋Cs A group were significantly higher than those in simple Cs A group,the difference was statistically significant（P〈0.05）.All the patients in ATG＋Cs A group had adverse reactions,15 cases of serum sickness,the infection rate was 60% during the treatment period,all the patients were improved after symptomatic treatment.There was no significant difference in the survival rates of ATG＋Cs A group and simple Cs A group（1 year,3 years,5 years）（P〈0.05）.Conclusion ATG and Cs A treatment has a fast onset of action and reaction rate and other advantages,and the adverse reactions can be tolerated,for that do not fully meet the supply of bone marrow,bleeding and infection in children with high risk is a kind of effective treatment method.

关 键 词：再生障碍性贫血 造血干细胞移植 免疫抑制 环胞素A 抗胸腺细胞球蛋白 

分 类 号：R725[医药卫生—儿科]