独子藤叶的二氯甲烷部位化学成分分析  

Chemical Constituents of Dichloromethane Extract From Leaf of Celastrus monospermus

作　　者：周琼[1] 王定勇[2] 张彦[2] 韩天娇[2] 陈燕忠[2] 吕竹芬[2] 谢清春[2] 

机构地区：[1]广州市第十二人民医院,广州510620 [2]广东药科大学广东省药物新剂型重点实验室,广州510006

出　　处：《中国实验方剂学杂志》2016年第14期64-69,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省科技计划项目(粤科规财字[2015]110号)

摘　　要：目的:研究独子藤叶二氯甲烷部位的化学成分,阐明其药效学物质基础。方法:独子藤叶甲醇提取物用二氯甲烷萃取浓缩成浸膏,经柱色谱硅胶用石油醚-乙酸乙酯溶剂体系进行梯度洗脱纯化,通过理化性质、波谱数据鉴定其结构。结果:得到11个化合物,分别为独子藤素A(1),丁香酸(2),丁香醛(3),香草酸(4),β-谷甾醇(5),胡萝卜苷(6),乌苏烷-3-酮-12-烯-28-酸甲酯(7),α,β香树脂醇(8),齐墩果烷-3-酮-12-烯-29-羧酸(9),tripterfrielanon A(10),3α,28-dihydroxy-olean^(-1)2-en-29-oic acid(11)。结论:得到11个化合物,其中化合物1为新化合物,化合物1~11均为首次从独子藤叶中获得。Objective： To study the chemical constituents of dichloromethane extract from the leaf of Celastrus monospermus and to clarify the basis of its efficacy substance. Method： Methanol extracts from the leaf of C. monospermus were obtained by using dichloromethane, and purified by gradient elution on silica gel column chromatography with petroleum ether-ethyl acetate system. Their structures were identified by their physical and chemical properties, as well as the spectral data. Result： Eleven compounds were isolated and identified as monosperme A （ 1 ）, syringic acid （2）, syringaldazin （3）, vanillic acid （4）,β-sitosterol （5）, daucosterol （6）, usu-12-en-3-one-28-methyl （7）, α,β-amyrin （8）, 3-oxo-olean-12-en-29-oic acid （9）, tripterfrielanon A （10）, and 3α, 28-dihydroxy-olean-12-en-29-oic acid （11）. Conclusion： The 11 compounds were obtained. Compound 1 was a new compound and other compounds were separated from the leaf of this plant for the first time.

关 键 词：独子藤 化学成分 结构鉴定 独子藤素A 新化合物 

分 类 号：R284.1[医药卫生—中药学]