金陵术治疗成人巨结肠的安全性和有效性  被引量:12

Efficacy and safety of the Jinling procedure in the treatment of adult Hirschsprung disease

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作  者:权斌[1] 陈启仪[1] 姜军[1] 倪玲[1] 唐蓉蓉[1] 黄裕[1] 史益凡 李宁[1] 

机构地区:[1]南京军区南京总医院普通外科研究所,210002

出  处:《中华胃肠外科杂志》2016年第7期763-768,共6页Chinese Journal of Gastrointestinal Surgery

基  金:全军临床高新技术重大项目(2010gxjs025);江苏省临床医学科技专项基金资助项目(BL2012006)

摘  要:目的探讨金陵术治疗成人巨结肠的安全性和有效性。方法总结2000年1月至2013年12月在南京军区南京总医院全军普通外科研究所接受金陵术治疗的125例成人巨结肠患者的临床和随访资料,所有巨结肠均经cT或钡灌肠、直肠肛管测压及病理检查等证实。分析对比手术前后的腹部症状、胃肠生活质量评分(GIQLI分值越低,生活质量越差)和Wexner便秘评分(分值越高,症状越重)、排粪造影情况(评估内容包括直肠前突、黏膜脱重、黏膜内套叠、会阴下垂等)以及手术并发症发生情况。结果125例患者男69例。女56例,年龄18~75(41.2±15.5)岁;病程(132.7±72.6)月。金陵术后第1、3、6和12月全组患者的随访率分别为94.4%(118/125)、92.0%(115/125)、89.6%(112/125)和88.0%(110/125)。腹胀和腹痛症状发生率术前分别为100%(125/125)和82.4%(103/125),术后持续降低,至术后第12月时,腹胀和腹痛发生率分别为7.3%(8/110)和20.9%(23/110)。术后1、3、6和12月Wexner便秘评分分别为8.7±2.9、7.2±2.8、6.7±2.2和6.3±1.6,明显优于术前的21.4±7.2(P〈0.01)。GIQLI评分术前为51.6±11.9,虽然术后1月时的评分47.3±5.5低于术前(P〈0.05),但术后3、6和12月时的评分已高于术前,分别为68.9±8.0、96.5±8.2和103.2±8.6(P〈0.01)。术后第3、6和12月排粪造影检查结果异常率分别为70.4%(81/115)、48.2%(54/112)和27.3%(30/110),显著低于术前的91.2%(114/125)(P〈0.01)。术后并发症发生率29.6%(37/125),其中手术部位感染5例(4.0%),腹腔出血2例(1.6%),吻合口瘘8例(6.4%,其中1例因严重腹腔感染而死亡),尿潴留4例(3.2%),便秘复发3例(2.4%,但无巨结肠复发),小肠梗阻11Objective To investigate the safety, efficacy and long-term outcomes of Jinling procedure in the treatment of adult Hirschsprung disease. Methods Clinical and follow-up data of 125 patients with adult Hirschsprung disease undergoing Jinling procedure at the Department of General Surgery between January 2000 and January 2013 were summarized. All the patients were diagnosed by CT, barium enema, anorectal pressure detection and pathology examination. Abdominal symptoms, gastrointestinal quality of life index (GIQLI, the lower score, the worse quality of life), Wexner constipation score (higher score indicated worse symptom), defecography (evaluation included rectocele, mucosal prolapse, intramucosal intussusception, perineal prolapse) and other operative complications were compared before and after operation. Results Among 125 patients, 69 were male and 56 were female with median age of (41.2 ± 15.5) (18 to 75) years. The follow-up rates were 94.4% (118/125),92.0% (115/125), 89.6% (112/125) and 88.0% (110/125) at postoperative months 1, 3, 6, and 12. Incidences of abdominal distension and abdominal pain were 100% and 82.4% (103/125) before operation, and were 7.3%(8/110) and 20.9%(23/110) at 12 months after surgery. Wexner score was significantly lower at postoperative months 1 (8.7 ± 2.9), 3 (7.2 ± 2.8), 6 (6.7 ± 2.2) and 12(6.3 ± 1.7) than that before operation (21.4 ± 7.2) (P 〈 0.01). GIQLI score was 51.6 ± 11.9 before operation, though it decreased at I month (47.3 ± 5.5)(P 〈 0.05) after surgery, but increased significantly at postoperative months 3, 6, 12 (68.9 ± 8.0, 96.5 ± 8.2, 103.2 ± 8.6)(P〈 0.01). Abnormal rate of defeeography was 70.4% (81/115), 48.2% (54/112) and 27.3% (30/110) at postoperative months 3, 6, 12, which was significantly lower than 91.2% (114/125) before operation (P〈 0.01 ). Morbidity of postoperative complication was 29.6% (37/125), including 5 eases of surgic

关 键 词:成人巨结肠 金陵术 术后并发症 长期随访 

分 类 号:R656.9[医药卫生—外科学]

 

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