异丙托溴胺联合布地奈德雾化吸入对病毒性肺炎患儿血清免疫球蛋白、T淋巴细胞和炎性因子的影响  

Therapeutic effects of compound ipratropium bromide atomization solution combined with budesonide suspension atomization inhalation on viral pneumonia in children and its effects on serum immune globulin,T lymphocyte subsets and inflammatory factors

作　　者：宋宏玲 

机构地区：[1]北京市昌平区东小口社区卫生服务中心,102200

出　　处：《河北医药》2016年第13期1946-1949,共4页Hebei Medical Journal

摘　　要：目的探讨复方异丙托溴胺雾化溶液联合布地奈德混悬液雾化吸入治疗病毒性肺炎,对患儿血清免疫球蛋白、T淋巴细胞亚群和炎性因子的影响及疗效。方法病毒性肺炎患儿205例随机分为对照组(n=103)和治疗组(n=102)。对照组进行病毒性肺炎的综合治疗,治疗组在对照组治疗基础上进行复方异丙托溴胺雾化溶液联合布地奈德混悬液雾化吸入治疗,比较2组治疗前后临床症状消失时间[呼吸困难(气促)、喘憋、咳嗽、肺部啰音消失时间]、血清免疫球蛋白(IgA、IgE、IgG、IgM)、T淋巴细胞亚群(CD_3^+、CD_4^+、CD_8^+和CD_4^+/CD_8^+)和炎性因子[白介素-6(IL-6)、白介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)]水平并进行疗效判定。结果治疗组呼吸困难(气促)、喘憋、咳嗽、肺部啰音消失时间明显低于对照组,差异有统计学意义(P<0.05)。对照组治疗后IgA、IgG水平高于治疗前,IgE水平低于治疗前,差异有统计学意义(P<0.05);治疗组治疗后IgA、IgG、IgM水平高于治疗前和对照组,IgE水平低于治疗前和对照组,差异有统计学意义(P<0.05)。2组治疗后CD_3^+、CD_4^+和CD_4^+/CD_8^+水平均高于治疗前,CD_8^+水平低于治疗前,差异有统计学意义(P<0.05)。治疗组治疗后CD_3^+、CD_4^+、CD_8^+和CD_4^+/CD_8^+水平与对照组比较,差异有统计学意义(P<0.05)。2组治疗后IL-6、IL-8、TNF-α水平均低于治疗前,且治疗组治疗后低于对照组,差异有统计学意义(P<0.05)。2组疗效比较差异有统计学意义(P<0.05),且治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。结论复方异丙托溴胺雾化溶液联合布地奈德混悬液雾化吸入治疗小儿病毒性肺炎能够明显减少临床症状持续时间、调节机体免疫功能,减少炎性反应,有利于患儿恢复。Objective To investigate the therapeutic effects of compound ipratropium bromide atomization solution combined with budesonide suspension atomization inhalation on viral pneumonia in children and its effects on serum immune globulin,T lymphocyte subsets and inflammatory factors. Methods Two hundred and five patients with viral pneumonia were randomly divided into control group（ n = 103） and treatment group（ n = 102）. The patients in control group were treated by comprehensive therapy,however,the patients in treatment group,on the basis of control group,were treated by compound ipratropium bromide atomization solution combined with budesonide suspension atomization inhalation. The extinction time of clinical symptoms including dyspnea,short breath,gasping,cough,extinction time of pulmonary rales,the levels of serum immune globulins（ IgA,IgE,IgG,IgM）,T lymphocyte subsets（ CD_3~＋,CD_4~＋,CD_8~＋ and CD_4~＋/CD_8~＋）,the serum levels of inflammatory factors（ IL-6,IL-8,TNF-α） were detected and compared between two groups before and after treatment. Moreover the therapeutic effects after treatment were observed and compared between two groups. Results After treatment the clinical symptoms including dyspnea,short breath,gasping,cough,extinction time of pulmonary rales in treatment group were significantly slighter than those in control group（ P 〈0. 05）. The levels of IgA and IgG in control group were significantly higher than those before treatment,however,the levels of IgE were obviously lower than those before treatment（ P 〈0. 05）.After treatment the levels of IgA,IgG,IgM in treatment group were significantly higher than those before treatment and those in control group,however,the levels of IgE were significantly lower than those before treatment and those in control group（ P 〈0. 05）. After treatment the levels of CD_3~＋,CD_4~＋,CD_4~＋/CD_8~＋ were obviously higher than those before treatment in both groups,however,the levels of CD＋8 were significantly lower than t

关 键 词：复方异丙托溴胺雾化溶液 布地奈德混悬液 雾化吸入 病毒性肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]