肥胖儿童血抵抗素与代谢指标的关系  

Relationship Between Serum Resistin Level and Metabolic Indices in Obese Children

作　　者：陆喜燕[1] 董国庆[1] 陈昱[1] 刘婉趋 钟丽华[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院儿科,广东深圳518028

出　　处：《罕少疾病杂志》2016年第4期1-2,11,共3页Journal of Rare and Uncommon Diseases

基　　金：深圳市科技计划项目(医疗卫生类)(课题编号:201303078)

摘　　要：目的探讨肥胖儿童血抵抗素与代谢指标的关系。方法选择单纯性肥胖儿童45例,同时选35例健康儿童为对照组。所有儿童清晨测量身高、体质量、腰围(WC)和臀围,计算体块指数(BMI)和腰臀比(WHR)、腰围身高比(WHt R),同时静脉采血检测血清胰岛素(FINS)、糖(FBG)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等,计算稳态模型胰岛素抵抗指数(HOMA-IR=FINS×FBG/22.5)。采用ELISA法测定血抵抗素浓度。结果单纯性肥胖儿童血清抵抗素浓度为27.76(17.35,53.23)ug·L^(-1),明显高于健康对照组的21.53(15.85,29.36)ug·L^(-1),Z=-2.076,P=0.038;抵抗素与BMI、WC、WHR、WHt R、血TG呈正相关,r分别=0.25、0.333、0.261、0.322、0.462,P分别=0.026、0.023、0.020、0.004、0.000,而与IR无相关性,r=0.180,P=0.112。结论抵抗素在肥胖儿童明显升高,其血液水平与肥胖程度及腹型肥胖、血TG水平密切相关。Objective To investigate the relationship between resistin and metabolic index in obese children. Methods Fortyfive cases of simple obese children and 35 healthy children of similar age and gender（control group） were enrolled. Their fasting height, body mass, waist circumference（WC） and hip circumference were measured, and body mass index（BMI）, waist to hip circumference ratio（WHR）, waist circumference to height ratio（WHt R） were calculated in the early morning. The serum levels of insulin（FINS）, sugar（FBG）, cholesterol（TC）, three acyl glycerin（TG）, highdensity lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C） were detected at same time, which contributed to the calculation of homeostasis model assessment-Insulin resistance（IR=FINS×FBG/22.5）. Serum resistin levels were measured by ELISA. Results Serun resistin level in obese group was 27.76（17.35, 53.23） ug·L-1, significantly higher than 21.53（15.85, 29.36） ug·L-1 of the healthy control, Z=-2.076, P=0.038. It was positively correlated with BMI, WC, WHR, WHt R and serum TG level, all P0.05, and no correlated with IR. Conclusion Serun resistin level obviously increase in obese children, and it was closely related to obesity degree（especially abdominal obesity） and serum TG level.

关 键 词：抵抗素 肥胖 代谢指标 儿童 

分 类 号：R723.14[医药卫生—儿科]