患儿颅内感染甘油果糖联合甘露醇降颅压的应用效果分析  

Application effect of glycerol and fructose in combination with mannitol to reduce intracranial pressure in children with intracranial infection

作　　者：钱立伟[1] 石红蕾[1] 洪丽[1] 杨延成[1] 汪学静[1] 

机构地区：[1]聊城市第二人民医院小儿科,山东聊城252600

出　　处：《中华医院感染学杂志》2016年第14期3328-3330,共3页Chinese Journal of Nosocomiology

基　　金：山东省卫生厅医学科研基金资助项目(HZ121)

摘　　要：目的通过比较分析小儿颅内感染甘油果糖、甘露醇以及甘油果糖联合甘露醇在临床上治疗降颅压中的效果,为小儿颅内感染患者降低颅压提供参考。方法选取2011年1月-2013年12月在医院接受颅内感染降颅压患儿87例作为研究对象,并随机分为3个治疗组:甘油果糖组、甘露醇组及甘油果糖联合甘露醇组(以下简称联合组),每组患儿29例,常规治疗基础上还做以下治疗:甘油果糖组患儿连续7d一疗程给予10%的甘油果糖液250ml,12h1次;甘露醇组连续7d一疗程静脉注射20%甘露醇注射液250ml,12h1次;联合组连续7d一疗程给予以10%的甘油果糖液250ml和20%甘露醇注射液250ml静脉滴注,6h1次,交替滴注,5d后全部改为使用甘油果糖液250ml,24h1次,7d后停药;以上治疗方法,三岁以下婴儿用药剂量减50.00%。结果 3组患儿在治疗前的临床均表现不同程度的颅内高压症状;3组患儿在治疗后总有效率比较,联合组的总有效率最高,即治疗效果最好;联合组患儿不良反应发生率13.80%,甘露醇组不良反应发生率65.52%,甘油果糖组不良反应发生率17.24%,故联合组不良反应发生率最低,综合说明联合组中治疗效果最好,以上差异均有统计学意义(P<0.05)。结论甘油果糖和甘露醇联合应用于治疗降低颅压效果好,能够缩短治疗疗程,并能降低不良反应的发生率。OBJECTIVE To comparatively analyze the effects of glycerol and fructose,mannitol and glycerin fructose joint mannitol to reduce intracranial pressure in children with intracranial infection glycerol,so as to provide a reference for clinical treatment of children with intracranial infection to reduce intracranial pressure.METHODS A total of 87 children with intracranial infection underwent treatment of reducing intracranial pressure in the hospital from Jan.2011-Dec.2013 were selected as research subjects,and were randomly divided into three treatment groups：glycerol fructose group,mannitol group and glycerol fructose joint mannitol group（joint group）,with 29 cases in each group On the basis of conventional therapy treatment,children in glycerol fructose group were given10% glycerol fructose liquid 250 ml continuous 7d,1time each 12 h,children in mannitol group were given 7dintravenous injection of 20% mannitol 250 ml continuous 7d,1time each 12 h,children in joint group were given10% glycerol fructose solution 250 ml and 20% mannitol injection 250 ml intravenously,1time each 6h,with alternating infusion,and all fructose was used instead of glycerol 250 ml after 5d,1time each 24 h,withdrawal after7 d.The dosage of above methods of treatment for infants under the age of three reduced to 50.00 %.RESULTS The three groups of children in pre-clinical treatment showed varying degrees of symptoms of intracranial hypertension.,The total efficiency rate of joint group was the highest after treatment.The incidence of adverse reactions of joint group,mannitol group and glycerol fructose group were 13.80%,65.52%,and 17.24%,respectively,so the joint group had the best treatment efficacy,and the differences were significant（P〈0.05）.CONCLUSION Glycerol fructose combined with mannitol have good treatment efficacy to reduce intracranial pressure,it can shorten the course of treatment,and can reduce the incidence of adverse reactions.

关 键 词：甘油果糖 甘露醇 联合用药 颅内感染 降颅压 

分 类 号：R983.1[医药卫生—药品]