胚胎移植前宫腔内注射艾泽在IVF-ET中的应用  

The Application of Intrauterine Injection before Embryo Transfer in IVF-ET Eiser

作　　者：毕星宇[1] 刘俊芬[1] 武学清[1] 

机构地区：[1]山西省妇幼保健院生殖医学中心,山西太原030001

出　　处：《中国医药指南》2016年第19期1-2,共2页Guide of China Medicine

基　　金：公益性行业科研专项(编号:201402004);山西省国际科技合作项目(编号:2011081070)资助

摘　　要：目的通过对反复着床失败的患者在胚胎移植前宫腔内注射艾泽观察临床结局的变化。方法对70例解冻周期和7例新鲜周期,在胚胎移植日或前1 d,宫腔注射艾泽100μg(0.5μg/μL)。然后行胚胎移植。观察临床结局。结果解冻周期妊娠率为21.4%(15/70);新鲜周期妊娠率为28.6%(2/7)。二者比较无统计学意义(P=0.064)。结论本研究因为样本量较少,结果无统计学差异。但是通过宫腔内注射艾泽帮助部分反复着床失败的患者获得了妊娠,可解决部分反复着床失败患者。Objective To observe the clinical outcome changes of intrauterine injection of human chorionic gonadotropin（HCG） before embryo transfer in repeated implantation failures. Methods 70 thaw cycles and 7 fresh cycles were injected HCG, 100 μg（0.5 μg/μL） on the day of embryo transfer or the day before transplantation. Then, these cases underwent ET and were observed the clinical outcomes. Result After HCG injection, the pregnancy rate was 21.4%（15/70） in thaw cycles and 28.6%（2/7） in fresh cycles. There were no significant differences of the pregnancy rate between the thaw cycles and the fresh cycles（P =0.064）. Conclusion Differences among these cycles＇ pregnancy were not significant because of the small sample size. However, intrauterine injection of HCG helped some patients with repeated implantation failure become pregnant. This treatment can be used in the patients with repeated implantation failure.

关 键 词：体外受精-胚胎移植 反复着床失败 宫腔注射 

分 类 号：R711.6[医药卫生—妇产科学]