静息心率对糖调节受损人群进展为糖尿病的影响  

Impact of resting heart rate on the progression to diabetes in impaired glucose regulation patients

作　　者：宋秋艳[1] 余玲[1] 董瑞鸿[1] 甄月巧[1] 桑艳红[1] 

机构地区：[1]郑州大学第五附属医院内分泌科,450000

出　　处：《中华内分泌代谢杂志》2016年第6期465-469,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：河南省医学科技攻关项目（2011020070）

摘　　要：目的探讨静息心率对糖调节受损人群进展为糖尿病的影响。方法选择2011年1月至2012年12月于郑州大学第五附属医院内分泌科门诊诊断的704例糖调节受损患者为研究对象。根据患者静息心率将患者分为4组：〈66次/min组、66~69次/min组、70~75次/min组及〉75次/min组。收集所有患者的基线资料,比较不同静息心率组间糖尿病的发病率,采用多因素回归分析静息心率与糖调节受损患者进展为糖尿病的关系。结果704例糖调节受损患者中,共636例患者完成2年的门诊随访,或达到随访终点（确诊为糖尿病）,随访率为90.34%。（1）随访2年期间,〈66次/min组、66~69次/min组、70~75次/min 组及〉75次/min 组糖尿病发生率分别为16.2%、19.4%、25.0%及33.0%,经 Cochran Armitage趋势检验,趋势χ^2=11.109,P=0.001。（2）根据入组患者血糖监测结果,将636例糖调节受损患者分为单纯空腹血糖受损组、单纯糖耐量受损组及空腹血糖受损＋糖耐量受损组：3组患者均随着静息心率的加快,糖尿病的发生率增高；其中空腹血糖受损＋糖耐量受损组患者进展为糖尿病的比例高于单纯空腹血糖受损组及单纯糖耐量受损组。68例进展为糖尿病的糖调节受损患者平均静息心率为（79.8±8.3）次/min,未进展为糖尿病的568例糖调节受损患者的平均静息心率为（74.5±7.2）次/min,差异有统计学意义（t=-5.043,P〈0.01）。（3）将患者是否进展为糖尿病作为应变量,以静息心率分组作为自变量,并以〈66次/min为参照,代入logistic回归分析。结果显示：随着静息心率的加快,糖调节受损患者进展为糖尿病的风险增大。结论静息心率增快是糖调节受损患者进展为糖尿病的危险因素。Objective To investigate the effect of resting heart rate on the progression to diabetes in impaired glucose regulation patients. Methods A total of 638 patients with impaired glucose regulation, from January 2011 to December 2012 in our endocrinology clinic, were selected for the study. According to the resting heart rate, patients were divided into four groups：〈66 beat/min group, 66 to 69 beat/min group, 70 to 75 beat/min group, and〉75 beat/min groups. All patients＆#39;baseline data were collected. The incidences of diabetes in different resting heart rate groups were compared, and the relationship between resting heart rate and the progression to diabetes was estimated using multiple regression analysis. Results In 704 patients with impaired glucose regulation, 636 patients have been completed 2 years follow-up, or reached the end of follow-up （ diagnosed as diabetes ） , the follow-up rate was 90. 34%. During two years follow-up, the incidence of diabetes of〈66 beat/min group, 66 to 69 beat/min group, 70 to 75 beat/min group, and〉75 beat/min group were 16. 2%, 19. 4%, 25. 0%, and 33. 0%, respectivlely. And the Cochran Armitage trend test showed that χ^2 =11. 109, P=0. 001, the difference was statistically significant （ P〈0. 05）. According to blood glucose monitoring, the 636 patients with impaired glucose regulation were divided into impaired fasting glucose group, impaired glucose tolerance group and impaired fasting glucose combined with impaired glucose tolerance group：the Cochran Armitage trend test showed that, with the resting heart rate accelerating, the incidence of diabetes increased. The incidence of diabetes in impaired fasting glucose combined with impaired glucose tolerance group was higher than that of impaired fasting glucose group and impaired glucose tolerance group （ P=0. 062, 0. 113）. The average resting heart rate in 68 impaired glucose regulation patients progressed to diabetes was （79.8±8.3）beat/min,andin568non-diabetescases,itwas（74.5±7.2）beat/min�

关 键 词：静息心率 糖调节受损 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]