血栓形成机制和临床抗栓策略的研究进展  

Developments of Thrombosis Mechanism and Clinical Antithrombotic Strategies

作　　者：贾斯达 袁晋青[1] 

机构地区：[1]北京协和医学院中国医学科学院国家心血管病中心阜外医院心内科,北京市100091

出　　处：《中国分子心脏病学杂志》2016年第3期1748-1752,共5页Molecular Cardiology of China

基　　金："十二五"国家科技支撑计划项目(2011BAI11B07);国家自然科学基金(81470486)

摘　　要：动脉粥样硬化和冠脉内血栓形成是冠心病中急性冠脉事件的主要发病机制。新型抗血小板药物和新型抗凝药物克服了传统药物的部分缺点,但其安全性、实际疗效仍有待大量的临床研究来证实。国际权威组织已逐渐将新型抗凝、抗血小板药物列入指南推荐。本文概述了血栓形成机制和临床抗栓策略的理论基础,介绍了新型和传统抗凝药物、抗血小板药物,列举了相关的研究证据,为专业人士提供参考。Atherosclerosis and thrombosis in coronary arteries are the major mechanisms in acute coronary events. New antiplatelet drugs and anticoagulants have overcome some of the shortcomings of traditional drugs, however, their safety and practical efficacy remains to be testified by massive clinical studies. International authoritative organizations are gradually enrolling new anticoagulants and antiplatelet drugs in guideline recommendations. In this review, we concluded the theoretic foundation of thrombotic mechanism and clinical antithrombotic strategies, introduced novel and traditional anticoagulants and antiplatelet drugs, listed relevant study evidences, to provide reference for professionals.

关 键 词：血栓形成 冠心病 抗栓治疗 

分 类 号：R541.4[医药卫生—心血管疾病]