职业性铅性肾损害敏感指标的基准剂量法筛选  

Application of benchmark dose on renal injury in people chronically exposed to lead

作　　者：董秋颖[1] 赵春香 郑卉 陈福尊 李增敏 李永辉 冀荷香 郝海燕 赵维 高俊卿 刘惠田 何洁 张晓娜 李建国 袁聚祥 

机构地区：[1]河北医科大学公共卫生学院,行家庄050017 [2]河北省疾病预防与控制中心 [3]华北理工大学

出　　处：《中华劳动卫生职业病杂志》2016年第7期494-497,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：河北省科技支撑计划、河北省重点职业病防治技术研究（13277709D）

摘　　要：目的用基准剂量法筛选职业性铅性肾损害的敏感指标。方法选择某蓄电池厂486人为研究对象，将其中116名不接铅者作为对照组。以血铅为暴露标志，以Uβ2-MG和UNAG为肾损害的效应标志；用基准剂量软件计算基准剂量反应为10％时，各效应标志物的血铅BMD和BMDL。结果接铅组与对照组血铅的差异有统计学意义（P〈0．05），将血铅水平按四分位间距法分组，各组UNAG的差异有统计学意义（P〈0．05）。随着血铅浓度增高Uβ-MG和UNAG异常率增高，经趋势x2检验，差异均有统计学意义（P〈0．05）.以Log-Probil为最优模型，计算血铅BMD／BMDL，当以uβ2-MG为效应指标时，血铅BMD／BMDL值为602．784-31．838μg／L；以UNAG为效应指标时，血铅BMD／BMDL值为130．398／100．981μg/L。结论职业铅接触会引起肾脏的损伤，而UNAG在检测肾功能损害的敏感性方面优于Uβ2-MG。Objective To screen sensitive indicators of renal injury in lead workers using benchmark dose method. Methods Of the 486 subjects,116 did not occupationally contact to lead as a control. The blood lead was considered as exposure biomarker, while Uβ2-MG and UNAG as effect biomarkers for renal injury. The BMD and BMDL of blood lead were estimated at the 10% benchmark response using BMDS Version 2.6 . Results There was statistical rise in blood lead between the lead group and control group （P〈0.05） ; and the blood lead level was divided into four groups by quarterback spacing method, among which UNAG was statistically different （P〈0.05）. There was an increased prevalence of abnormal rates of Uβ2-MG and UNAG with increasing blood lead concentration （P〈0.05）, after trend chi-square test. BMD and BMDL of UNAG and Uβ2- MG were 602.784/431.838 μg/L and 130.398/100.981 μg/L caculated by Log-Probit model, respectively. Conclusions Occupational lead exposure may cause kidney damage, and UNAG could be as a more sensitive marker for monitoring early renal injury than Uβ2-MG.

关 键 词：铅 基准剂量 Β2-微球蛋白 N+乙酰-β—D-氨基葡萄糖苷酶 

分 类 号：R135.1[医药卫生—劳动卫生]