血尿酸水平与阵发性心房颤动患者射频消融术后复发的关系  

Relationship Between Serum Uric Acid Level and Recurrence of Patients With Paroxysmal Atrial Fibrillation After Radiofrequency Ablation

作　　者：胡晓[1] 张静 丁志坚[1] 

机构地区：[1]南京医科大学附属常州市第二人民医院心血管内科,江苏省常州市213000 [2]江苏护理职业学院

出　　处：《中国全科医学》2016年第19期2275-2278,共4页Chinese General Practice

摘　　要：目的探讨血尿酸(SUA)水平与阵发性心房颤动患者射频消融术后复发的关系。方法选取2011年6月—2014年1月在南京医科大学附属常州市第二人民医院行射频消融术治疗的91例阵发性心房颤动患者为研究对象。术后3个月经心电图或24 h动态心电图检查确定有无心房颤动复发,将患者分为复发组(20例)和未复发组(71例)。详细记录患者的临床资料,分别于术前及术后1周、6个月抽取清晨空腹静脉血检测SUA、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)水平。结果复发组年龄、病程、左心房前后径(LAD)大于未复发组(P<0.05)。复发组术前、术后1周及术后6个月SUA、hs-CRP水平高于未复发组,复发组术前WBC水平高于未复发组(P<0.05)。复发组术后1周SUA、hs-CRP水平高于术前,术后6个月SUA、hs-CRP水平低于术后1周(P<0.05)。未复发组术后1周SUA水平高于术前,术后6个月SUA水平低于术前和术后1周(P<0.05);术后1周hs-CRP水平高于术前,术后6个月hs-CRP水平低于术后1周(P<0.05)。多因素Logistic回归分析结果显示,LAD〔OR=1.945,95%CI(1.047,3.612)〕及术前SUA〔OR=1.024,95%CI(1.009,1.038)〕、hs-CRP〔OR=4.762,95%CI(1.359,16.685)〕水平是阵发性心房颤动患者射频消融术后复发的独立危险因素(P<0.05)。结论术前高SUA水平是阵发性心房颤动患者射频消融术后复发的独立预测因子,降低SUA水平可能会改善心房颤动患者的预后,降低射频消融术后的复发率。Objective To establish the relation between serum uric acid （SUA） level and the recurrence of patients with paroxysmal atrial fibrillation after radiofrequency ablation. Methods From June 2011 to January 2014, we enrolled 91 paroxysmal atrial fibrillation patients who received radiofrequency ablation in Changzhou Second People＇s Hospital Affiliated to Nanjing Medical University. Three months after the operation, electrocardiogram or 24 h dynamic electrocardiogram were conducted to determine whether atrial fibrillation recurred, and divided the patients into recurrence group （ n = 20） and non - recurrence group （ n = 71 ） . The clinical data of patients were recorded in detail. Early - morning fasting venous blood was sampled before the operation, one week and 6 months after the operation to determine SUA, hs-CRP and WBC level Results The recurrence group had higher age, longer disease course and larger LAD than non - recurrence group （ P 〈 0. 05 ）. The recurrence group had higher SUA and hs-CRP level than the non - recurence group before the operation, one week and 6 months after the operation, and the recurrence group was higher than non - recurrence group in WBC level before the operation （ P 〈 0. 05 ）. The SUA and hs-CRP level of the recurrence group one week after the operation were higher than those before the operation, and the SUA and hs-CRP level of the recurrence group six months after the operation were lower than those one week after the operation （ P 〈 0. 05 ）. The SUA level of non - recurrence group one week after operation was higher than that before the operation, and the SUA level of non - recurrence group six months after operation was lower than that before the operation and one week after the operation （ P 〈 0. 05 ） . The hs-CRP level of the non - recurrence group one week after the operation was higher than that before the operation, and the hs-CRP level of the non - recurrence group six months after the operation were lower than those one week after the o

关 键 词：心房颤动 尿酸 导管消融术 复发 

分 类 号：R541.75[医药卫生—心血管疾病]