阿朴酯关键中间体C5磷盐的合成  

Synthesis of C5 Phosphate Salt

作　　者：刘笑 吕国锋 黄国东 

机构地区：[1]杭州湾上虞经济技术开发区管委会,浙江上虞312369 [2]上虞新和成生物化工有限公司,浙江上虞312369

出　　处：《广州化工》2016年第13期90-92,共3页GuangZhou Chemical Industry

摘　　要：β-阿朴-8'-胡萝卜素的应用越来越广,诸多的合成方法各有优缺点,采用C25+C5的合成路线,其关键中体间C5磷盐的合成是一个瓶颈,本文以2-乙烯基丙腈为原料经乙醇为溶剂氰基醇解酯化,溴代后与亚磷酸三乙酯成盐得到C5磷盐纯度达98.70%,总收率达49.80%,具有工艺路线短、原料易得、反应条件温和、收率高的优点。β-Apo-8＇-Carotenoic Acid Ethyl Ester has been more widely used today.There are many methods for synthesis of it and each has its advantages and disadvantages.One way is employing C25 ＋ C5 to prepare.However,as the key intermediate,the synthesis of C5 phosphate salt is still a bottle-neck issue.C5 phosphate salt was prepared as follows：cyano alcoholysis esterification first took place with 2-ethyl-3-butenenitril as the reactant and ethyl alcohol as the solvent,after bromination,it went to react with triethyl phosphate to produce C5 phosphate salt.It turned out that the purity of the product reached as high as 98.70 % and total yield exceeded 49.80 %.This approach was characterized by short process.The raw material had the advantages of easy to get,mild reaction conditions and high yield.

关 键 词：阿朴酯 C5磷盐 2-乙烯基丙腈 

分 类 号：TQ46[化学工程—制药化工]