注射用多尼培南体内抗菌活性研究  

Study on Antibacterial Activity of Doripenem for Injection in vivo

作　　者：黄丽平[1] 林明琴[1] 沙莹 刘月丽[1] 

机构地区：[1]海南医学院药学院药理学教研室,海口571101 [2]海口市制药厂,海口570311

出　　处：《国外医药（抗生素分册）》2016年第4期165-168,共4页World Notes on Antibiotics

基　　金：国家自然科学基金项目(No.81260060);海南省自然科学基金项目(No.813186)

摘　　要：目的评价注射用多尼培南的体内抗菌活性。方法建立小鼠腹腔感染模型,以注射用美罗培南为对照药,观察注射用多尼培南的体内抗菌活性。结果注射用多尼培南对大肠埃希菌DC01、DC02和甲氧西林敏感的金黄色葡萄球菌JP02有良好的体内抗菌活性,其ED_(50)分别为4.5、1.0和2.0 mg/kg,美罗培南为15.9、10.6和17.3 mg/kg。阴性对照对感染小鼠无保护作用。结论注射用多尼培南对大肠埃希菌和甲氧西林敏感的金黄色葡萄球菌所致的小鼠腹腔感染具有良好的治疗作用,其体内抗菌活性优于同类对照药。Objective To evaluate the antibacterial activity of doripenem injection in vivo. Methods Using meropenem injection as positive control drug, the observation group received doripenem injection and was evaluated its protective effects on different bacteria in mice. Results Doripenem injection showed a higher antibacterial activity in the mice-infected by Escherichia coli DC01 , DC02 and methicillin-sensitive Staphylococcus aureus JP02 compared with that of the meropenem injection.The ED50 of doripenem injection for each bacterium was 4.5, 1.0 and 2.0 mg/kg respectively; while, that of meropenem was 15.9, 10.6 and 17.3 mg/kg.. The negative control had no protective effect on the infected mice. Conclusions Doripenem injection is an effective therapeutic agent in treating the mice infected by Escherichia coli and Staphylococcus aureus.

关 键 词：多尼培南 美罗培南 抗菌活性 体内抗菌 

分 类 号：R978.1[医药卫生—药品]