茵陈蒿汤加减联合人工肝治疗亚急性重型肝炎疗效观察  

Curative Effects of Yinchenhao Decoction Combined with Artificial Liver in Treatment of Subacute Severe Hepatitis

作　　者：刘卫华[1] 朱清静[2] 

机构地区：[1]武汉市医疗救治中心护理部,湖北武汉430023 [2]武汉市医疗救治中心肝病科,湖北武汉430023

出　　处：《辽宁中医杂志》2016年第7期1410-1413,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：湖北省自然科学基金(2009CD3129)

摘　　要：目的:探讨茵陈蒿汤加减治疗人工肝治疗亚急性重型肝炎的临床效果。方法:选择2011年3月—2015年2月本院收治的60例亚急性重型肝炎患者作为研究对象,按入院单双日均分为对照组与观察组,每组30例。两组均给予基础治疗,予以人工肝支持疗法,观察组在此基础上加用茵陈蒿汤加减,监测两组肝肾功能、凝血功能的变化,记录治疗前后丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、血清蛋白(ALB)、肌酐(Cr)、乙型肝炎病毒(HBV-DNA)、凝血酶原活动度(PTA)、凝血酶原时间(PT)等指标的变化,评定两组治疗效果,统计治疗不良反应。结果:1观察组治疗有效率为90.0%,高于对照组的66.7%(P<0.05);2两组治疗后ALT、AST、TBIL、DBIL、Cr均降低,观察组降低幅度高于对照组(P<0.05),两组ALB均上升,观察组上升幅度低于对照组(P<0.05);3治疗后,两组HBV DNA、PTA降低,PT缩短,观察组各指标变化幅度均高于对照组(P<0.05);4两组均未见严重不良反应,各不良反应发生率对比差异无统计学意义(P>0.05)。结论:茵陈蒿汤加减联合人工肝治疗亚急性重型肝炎,可显著改善患者肝肾、凝血功能,且安全性高。Objective： To explore the clinical effects of Modified Yinchenhao Decoction combined with artificial liver in the treatment of subacute severe hepatitis. Methods： Sixty cases of patients with subacute severe hepatitis who were treated in our hospital between March 2011 and February 2015 were selected as the study objects. According to the odd or even day of admission,the patients were divided into control group and observation group,30 cases in each group. Both of the two groups were given basic treatment and artificial liver support therapy. On this basis,the observation group was treated with Modified Yinchenhao Decoction. The changes of liver and kidney function and blood coagulation function in the two groups were monitored. The changes of alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBIL）,direct bilirubin（ DBIL）,serum albumin（ ALB）,creatinine（ CR）,hepatitis B virus（ HBV- DNA）,prothrombin activity（ PTA） and prothrombin time（ PT） and so on before and after treatment were recorded. The therapeutic effects of the two groups were evaluated and the adverse reactions were statistically analyzed. Results： ①The effective rate of treatment in the observation group（ 90. 0%） was higher than that in the control group（ 66. 7%）（ P〈0. 05）. ②After treatment,levels of ALT,AST,TBIL,DBIL and Cr in the two groups decreased.The decreased range in the observation group was greater than that in the control group（ P〈0. 05）. ALB in the two groups increased and the increased range in the observation group was lower than that in the control group（ P〈0. 05）. ④After treatment,HBV DNA and PTA decreased and PT shortened. The varied ranges of indexes in the observation group were greater than those in the control group（ P〈0. 05）. ④There was no serious adverse reactions in the two groups and there was no significant difference in the incidence of adverse reactions（ P〉0. 05）. Conclusion： To apply Modified Yinchenhao De

关 键 词：肝炎 亚急性 茵陈蒿汤 人工肝 血浆置换 

分 类 号：R285.6[医药卫生—中药学]