5-羟色胺转运体基因多态性与生活事件对青少年抑郁情绪的影响  

The impact of Serotonin transporter gene linked polymorphic region and life events on adolescents' depression mood

作　　者：王艳芬[1] 马丽荣[1] 张芸[1] 

机构地区：[1]西北民族大学医学院,甘肃兰州730030

出　　处：《中国学校卫生》2016年第7期1005-1007,1011,共4页Chinese Journal of School Health

摘　　要：目的探讨青少年抑郁情绪与5-羟色胺转运体基因启动子区多态性(5-HTTLPR)及生活事件之间的关系,为青少年精神卫生领域研究提供实证依据。方法于2013年9月至2014年1月期间,随机选取兰州市537名健康中学生开展抑郁量表(CES-D)、青少年生活事件自评量表(ASLEC)等问卷调查,并刮取口腔黏膜进行DNA提取及5-HTTLPR基因分型。结果中学生5-HTTLPR的SS,SL和LL 3种基因型检出率分别为56.43%,36.31%,7.26%。女生抑郁得分(42.12±10.29)高于男生(38.40±8.83)(t=-4.438,P<0.01)。5-HTTLPR 3种基因型抑郁得分差异无统计学意义(F=1.998,P=0.137)。生活事件对男、女生抑郁情绪有影响(t值分别为-5.159,-7.720,P值均<0.01),未发现5-HTTLPR基因型和生活事件对男、女生抑郁情绪存在交互作用(F值分别为1.147,1.133,P值均>0.05)。结论 5-HTTLPR与健康青少年抑郁情绪相关性还需进一步探讨。Objective The effect of serotonin transporter gene linked polymorphic region（ 5-HTTLPR） and life events on adolescent＇s depression mood was investigated. Methods Totally 568 healthy Han middle school students were enrolled randomly from Sep, 2013 to Jan, 2014 in Lanzhou city. All the participants finished CES-D（ Center for Epidemiological studies Depression Scale） and ASLEC（ Adolescent Self-Rating Life Events Check List）. DNA was extracted from buccal mucous and 5-HTTLPR was genotyped. The effects of life events, 5-HTTLPR genotypes, and their G-E interaction effect on adolescents＇ depression were analyzed with ANOVA. Results The checking rates of middle school students about 5-HTTLPR three genotypes, including SS,SL and LL, were 56.43%, 36.31% and 7.26% respectively. Depression scores were significantly higher among females（ 42.12±10.29）than males（ 38.40±8.83）（ t =- 4. 438,P〈0. 01）. There was no significant difference of depression scores among 5-HTTLPR three genotypes（ F = 1.998,P = 0.137）. Life events had a significant main effect on depression scores（ t =- 5.15,- 7.720,P〈0.01）. There was no significant interactive effect between 5-HTTLPR and life events on depression scores（ F = 1.147,1.133,P〈0.05）. Conclusion The association between 5-HTTLPR and depression mood among healthy adolescents yet to be discussed.

关 键 词：多态性 单核苷酸 生活变动事件 抑郁 学生 

分 类 号：R395.6[哲学宗教—心理学] R749.41[医药卫生—医学心理学]