136例尿道口尖锐湿疣流行病学分析及5-氨基酮戊酸光动力治疗疗效  

Epidemiological analysis of 136 patients with urethral condyloma acuminatum and evaluation of efficacy of photodynamic therapy with topical 5-aminolevulinic acid

作　　者：张云杰[1] 林卉[1] 郭晓娟[1] 邹先彪[1] 

机构地区：[1]解放军总医院第一附属医院皮肤科,北京100048

出　　处：《传染病信息》2016年第3期173-175,共3页Infectious Disease Information

基　　金：解放军总医院临床科研扶持基金(三○四专项)临床优势技术项目(2015FC-TSYS-3045)

摘　　要：目的分析136例尿道口尖锐湿疣患者情况,并评价其5-氨基酮戊酸光动力疗法治疗的临床疗效。方法回顾性分析2013年1月—2014年12月在我科接受5-氨基酮戊酸光动力治疗的136例尿道口尖锐湿疣的患者的临床资料,分析其流行病学特点,并总结疗效。结果 136例尿道口尖锐湿疣中HPV DNA分型以6型和11型为主;20-40岁男性患者占绝大多数;传播方式以性传播为主。患者接受5-氨基酮戊酸光动力治疗结束后疣体完全消退,随访6个月复发率为4.4%,随访12个月后未见复发患者,治愈率100%。主要不良反应为照射部位水肿、疼痛及红斑。结论尿道口尖锐湿疣主要由性传播引起,5-氨基酮戊酸光动力疗法治疗尿道口尖锐湿疣清除率高、不良反应小,可作为尿道口尖锐湿疣的治疗选择。Objective To analyze 136 patients with urethral condyloma acuminatum, and evaluate the efficacy of photodynamic therapy（PDT） with topical 5-aminolevulinic acid（ALA） on urethral condyloma acuminatum. Methods A retrospective analysis was made for 136 patients with urethral condyloma acuminatum treated with topical ALA-PDT in our department from January 2013 to December 2014. The epidemiological characteristics and the efficacy were analyzed. Results Of the 136 patients with urethral condyloma acuminatum, HPV-DNA type 6 and type 11 dominated, male patients aged 20-40 years old accounted for the majority, and sexual transmission was the main mode of transmission. After being treated with topical ALA-PDT, the warts disappeared completely. During the 6-month follow-up after the treatment, the recurrence rate was 4.4%; after 12-month follow-up, no recurrence was found with a curative rate of 100%. The main adverse reactions of ALA-PDT included edema, pain and erythema on local skin. Conclusions Urethral condyloma acuminatum is mainly caused by sexual transmission. ALA-PDT is an effective and safe therapy for urethral condyloma acuminatum, with a higher rate of wart elimination and fewer adverse reactions.

关 键 词：尖锐湿疣 性传播疾病 光化学疗法 

分 类 号：R453[医药卫生—治疗学] R752.53[医药卫生—临床医学]