含铋剂四联疗法治疗消化性溃疡并幽门螺杆菌感染的效果观察  

Efficacy of bismuth containing quadruple therapy in the treatment of peptic ulcer in patients with Helicobact-er pylori

作　　者：江明万[1] 于双[1] 王晴雷[1] 刘辉[1] 代克行 

机构地区：[1]重庆三峡中心医院消化内科,重庆市404000

出　　处：《中国基层医药》2016年第15期2297-2300,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探究含铋剂四联疗法治疗幽门螺杆菌（H．pylori）感染的消化性溃疡的疗效。方法选取 H．pylori 感染的消化性溃疡患者307例，应用随机数字表法将患者分为观察组（152例）和对照组（155例）。观察组：胶体果胶铋、泮托拉唑、阿莫西林、呋喃唑酮、四联疗法，疗程14 d；对照组：泮托拉唑、克拉霉素、阿莫西林、标准三联疗法，疗程14 d。将观察组和对照组溃疡总有效率、H．pylori 根除率及相关不良反应进行比较。结果观察组溃疡愈合率、症状缓解率、H．pylori 根除率分别为93．5％、92．7％、94．8％、92．3％，对照组溃疡愈合率、症状缓解率、H．pylori 根除率分别为83．4％、82．7％、84．1％、80．6％，两组差异均有统计学意义（χ2＝4．15、4．96、0．94，均 P ＜0．05），两组药物不良反应发生率差异无统计学意义（P ＞0．05）。结论含铋剂四联疗法治疗 H．pylori 感染的消化性溃疡疗效显著，值得临床推广。Objective To explore the efficacy of bismuth containing quadruple therapy in the treatment of peptic ulcer in patients with Helicobacter pylori.Methods We selected 307 peptic ulcer patients with Helicobacter pylori.infection,and randomly divided them into observation group （152 cases）and control group （155 cases）.The observation group received quadruple therapy：colloidal bismuth pectin,pantoprazole,amoxicillin and furazolidone, 14d.The control group received the standard triple therapy：pantoprazole,clarithromycin and amoxicillin,14d.The ulcer healing rate,H.pylori eradication rate and adverse reaction were compared between the two groups.Results The ulcer healing rates,remission rates,H.pylori eradication rates in the observation group were 93.5%,92.7%, 94.8%,92.3% respectively,which in the control group were 83.4%,82.7%,84.1%,80.6% respectively,there were statistically significant differences （χ2 =4.15,4.9,6,0.94,all P 〈0.05）.The incidence of adverse reactions did not differ significantly between the two groups （P 〉0.05）.Conclusion Bismuth containing quadruple therapy is associated with a higher rate of H.pylori eradication compared with the standard triple therapy.

关 键 词：胶体果胶铋 四联疗法 消化性溃疡 幽门螺杆菌 

分 类 号：R573.1[医药卫生—消化系统]